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Fig. 4 | Cancer Cell International

Fig. 4

From: Long noncoding RNA SNHG17 induced by YY1 facilitates the glioma progression through targeting miR-506-3p/CTNNB1 axis to activate Wnt/β-catenin signaling pathway

Fig. 4

SNHG17 up-regulated the expression of CTNNB1 by sponging miR-506-3p. a CTNNB1 expression was tested to be up-regulated in glioma tissues and cell lines. b Pearson’s correlation analysis demonstrated that CTNNB1 expression had a positive correlation with SNHG16 expression. c StarBase database uncovered 20 putative miRNAs was predicted to not only be sponged by SNHG17 but also targeted CTNNB1. d RT-qPCR exhibited the expressions of miR-506-3p, miR-330-3p, miR-3619-5p and miR-2116-3p in glioma cells. e RT-qPCR unveiled that the expression of miR-506-3p was down-regulated in glioma tissues. f Pearson’s correlation analysis illustrated that miR-506-3p expression was negatively associated with SNHG17 and CTNNB1. g RIP assay displayed that SNHG17, miR-506-3p and CTNNB1 were together enriched in RISC complex. h RT-qPCR showed that miR-506-3p was overexpressed by miR-506-3p mimics. i The binding site for SNHG17 and miR-506-3p as well as the binding site for miR-506-3p and CTNNB1 were exhibited (j) Luciferase reporter assay illustrated that SNHG17 competitively bound with miR-506-3p to up-regulate CTNNB1. **P < 0.01

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Cancer Cell International

ISSN: 1475-2867

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