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Fig. 5 | Cancer Cell International

Fig. 5

From: Long noncoding RNA SNHG17 induced by YY1 facilitates the glioma progression through targeting miR-506-3p/CTNNB1 axis to activate Wnt/β-catenin signaling pathway

Fig. 5

Overexpression of CTNNB1 rescued the SNHG17 depletion mediated inhibition on the progression of glioma. a RT-qPCR manifested that CTNNB1 was effectively up-regulated in glioma cells. b–d The inhibitory effect on cell proliferation caused by SNHG17 silence was countervailed by overexpression of CTNNB1. e, f Flow cytometry and TUNEL assays illustrated that the up-regulation of CTNNB1 abrogated the suppression of SNHG17 induced increase of cell apoptosis in U87 cells. g Western blot assay corroborated that attenuation of SNHG17 promoted the protein expression of cleaved-caspase3, cleaved-caspase9 and Bax, while overexpression of CTNNB1 reversed this effect. h The tumor growth curve indicted tumor size was suppressed by ablation of SNHG17 in vivo. i, j Tumor volume and tumor weight were both blocked as a result of SNHG17 knockdown. k RT-qPCR showed SNHG17 and CTNNB1 expression was reduced while miR-506-3p expression was induced by SNHG17 knockdown in glioma tissues. **P < 0.01

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Cancer Cell International

ISSN: 1475-2867

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