Fig. 1
From: Microsatellite instability: a review of what the oncologist should know
Lynch syndrome screening process. Lynch syndrome screening process. MMR immunohistochemical method is used to detect whether 4 MMR proteins of hMLH1, hPMS2, hMSH2 and hMSH6 are missing, and whether BRAF V600E mutation exists in hMLH1 negative protein and whether EpCAM mutation exists in hMLH1 positive protein, so as to determine whether there is MMR functional defect. MSI detection is to determine the stability of MSI sites by detecting nucleotide marker: two of the unstable loci were MSI-H, the instability of one of the loci was MSI-L, MSS was defined as the instability of zero loci. MMR mismatch repair, MSI-H microsatellite high instability, MSI-L microsatellite low instability, MSS microsatellite stability