Development of a risk scoring system for evaluating the prognosis of patients with Her2-positive breast cancer

Table 2 Gene ontology analysis of mRNAs associated with HER2-positive breast cancer

Category	Term	Count	P value
GOTERM_BP_DIRECT	GO:0007165 ~ signal transduction	61	0.028781941
	GO:0045944 ~ positive regulation of transcription from RNA polymerase II promoter	55	0.012328036
	GO:0051301 ~ cell division	43	2.54E−10
	GO:0008284 ~ positive regulation of cell proliferation	43	9.78E−07
	GO:0000122 ~ negative regulation of transcription from RNA polymerase II promoter	41	0.025358743
GOTERM_CC_DIRECT	GO:0070062 ~ extracellular exosome	168	2.12E−08
	GO:0005576 ~ extracellular region	160	2.27E−28
	GO:0005615 ~ extracellular space	147	3.61E−30
	GO:0005578 ~ proteinaceous extracellular matrix	43	2.09E−14
	GO:0031012 ~ extracellular matrix	39	1.74E−10
GOTERM_MF_DIRECT	GO:0005515 ~ protein binding	379	0.003363112
	GO:0005509 ~ calcium ion binding	61	2.17E−08
	GO:0042802 ~ identical protein binding	43	0.012433807
	GO:0042803 ~ protein homodimerization activity	42	0.01295918
	GO:0046982 ~ protein heterodimerization activity	35	3.60E−04

^aIf there were more than five terms enriched in this category, top five terms were selected according to count value

ISSN: 1475-2867