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Fig. 5 | Cancer Cell International

Fig. 5

From: The histone demethylase JMJD2A promotes glioma cell growth via targeting Akt-mTOR signaling

Fig. 5

JMJD2A facilitates the activation of the Akt-mTOR pathway in glioma. a Akt-mTOR pathway is activated in human glioma tissues (n = 4) compared with the control (n = 4). b Quantitative results of the protein levels in (a). **p < 0.01 vs. Normal. n = 4 in each group. c Correlation analysis of JMJD2A protein level and mTOR activation in glioma tissues and control brain tissues (n = 8). dJMJD2A knockdown represses the activation of the Akt-mTOR pathway in U87MG glioma cells. U87MG cells were infected with lentivirus expressing sh-Ctrl or sh-JMJD2A for 48 h. eJMJD2A overexpression promotes the activation of the Akt-mTOR pathway in U87MG glioma cells. U87MG cells were infected with lentivirus expressing ctrl or JMJD2A for 48 h. fJMJD2A knockdown represses protein synthesis in glioma cells. U87MG, T98G, and U251 cells were infected with lentivirus expressing sh-ctrl or sh-JMJD2A for 24 h and then protein synthesis assay was performed with the incorporation of [3H]-leucine for 24 h. **p < 0.01 vs. sh-ctrl

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