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Fig. 6 | Cancer Cell International

Fig. 6

From: The histone demethylase JMJD2A promotes glioma cell growth via targeting Akt-mTOR signaling

Fig. 6

Rapamycin blocks the effects of JMJD2A on glioma cell growth and colony formation. a Inhibition of mTOR with rapamycin blocks the effects of JMJD2A on protein synthesis in U87MG glioma cells. U87MG cells were pretreated with rapamycin (1 μM) for 12 h followed by lentivirus infection and protein synthesis assay. **p < 0.01 vs. ctrl + PBS; #p < 0.05 vs. ctrl + PBS. b Inhibition of mTOR with rapamycin blocks the effects of JMJD2A on the proliferation of U87MG cells. U87MG cells were pretreated with rapamycin (1 μM) for 12 h followed by lentivirus infection and proliferation assay. *p < 0.05, **p < 0.01 vs. Ctrl + PBS; #p < 0.05, ##p < 0.01 vs. ctrl + PBS. c Inhibition of mTOR with rapamycin blocks the effects of JMJD2A on colony formation of U87MG cells. U87MG cells with/without JMJD2A overexpression were subjected to colony formation assay in the presence/absence of rapamycin (1 μM). **p < 0.01 vs. ctrl + PBS; ##p < 0.01 vs. ctrl + PBS

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