Fig. 6

CircVAPA-mediated glycolysis was regulated by miR-125a/CREB5 axis. a, b The change of ECAR level was measured in HCT116 and LOVOcells transfected with si-con, si-circVAPA, si-circVAPA + anti-miR-con, si-circVAPA + anti-miR-125a, si-circVAPA + vector and si-circVAPA + CREB5. c, d The change of OCR was detected in transfected HCT116 and LOVO cells. e, f Glucose uptake was examined in transfected HCT116 and LOVO cells. g, h The production of lactate was detected in transfected HCT116 and LOVO cells. i, j ATP was determined in transfected HCT116 and LOVO cells. *P < 0.05