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Fig. 4 | Cancer Cell International

Fig. 4

From: Expression profile analysis identifies key genes as prognostic markers for metastasis of osteosarcoma

Fig. 4

Identification of key genes based on training set. a A scatterplot of Gene Significance (GS) for weight vs. Module Membership (MM) in the blue module. There is a highly significant correlation between GS and MM in this module. b Volcano plot of significance of gene expression difference between metastasis and non-Metastasis patients. A gene is considered significantly differentially expressed if its |log(FC)| > 1 and p-value < 0.05. c Overall survival analysis of 4 key genes. Expression levels of ALOX5AP, HLA-DMB, HLA-DRA and SPINT2 are significantly related to the overall survival of patients with OS (P < 0.05). d Boxplot of significance of gene expression levels of 4 key genes. ALOX5AP, HLA-DMB, HLA-DRA and SPINT2 are significantly downregulated in metastasis OS compared with non-metastasis OS. The **** represents P < 0.0001. e ROC curves analysis of 4 key genes diagnosis. ROC curves and AUC statistics are used to evaluate the capacity to discriminate OS with or without metastasis with excellent specificity and sensitivity. f The network illustrates the relationship of 4 key genes and the 36 most frequently altered neighbor genes. The 4 key genes are presented in red and orange depending on the gene importance defined as the degree of connectivity. The other genes are represented in blue and green

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