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Table 6 Correlation analysis between CLEC3B and relate genes and markers of immune cells in TIMER

From: CLEC3B as a potential diagnostic and prognostic biomarker in lung cancer and association with the immune microenvironment

Description Gene markers ADC SCC
None Purity None Purity
Cor P Cor P Cor P Cor P
CD8+ T cell CD8A 0.07 0.113 0.003 0.95 0.322 *** 0.238 ***
CD8B 0.08 0.071 0.035 0.438 0.276 *** 0.232 ***
CD45 0.2 *** 0.126 ** 0.447 *** 0.361 ***
T cell (general) CD3D 0.138 * 0.066 0.144 0.382 *** 0.279 ***
CD3E 0.168 ** 0.101 0.024 0.397 *** 0.294 ***
CD2 0.155 ** 0.083 0.067 0.382 *** 0.282 ***
B cell CD19 0.194 *** 0.145 * 0.414 *** 0.316 ***
CD79A 0.154 ** 0.105 0.020 0.385 *** 0.279 ***
CD27 0.148 *** 0.091 * 0.384 *** 0.289 ***
CD20 0.293 *** 0.249 *** 0.481 *** 0.415 ***
Monocyte CD14 0.065 0.139 0 0.994 0.391 *** 0.281 ***
CD115 (CSF1R) 0.11 0.012 0.04 0.373 0.449 *** 0.357 ***
TAM CCL2 0.03 0.5 − 0.036 0.419 0.31 *** 0.229 ***
CD68 0.165 ** 0.11 0.015 0.372 *** 0.27 ***
IL10 0.198 *** 0.132 * 0.41 *** 0.335 ***
M1 Macrophage INOS (NOS2) 0.236 *** 0.23 *** 0.11 0.014 0.116 0.011
CD80 0.101 * 0.021 0.643 0.302 *** 0.217 ***
IRF5 0.037 0.4 − 0.021 0.635 0.152 ** 0.116 0.011
IL6 0.02 0.659 − 0.02 0.658 0.203 *** 0.154 ***
CD64 (FCGR1A) 0.012 0.792 − 0.069 0.127 0.404 *** 0.316 ***
M2 Macrophage CD163 0.098 0.026 0.028 0.529 0.46 *** 0.373 ***
CD206 0.306 *** 0.256 *** 0.456 *** 0.374 ***
VSIG4 0.162 ** 0.102 0.023 0.478 *** 0.4 ***
MS4A4A 0.233 *** 0.175 *** 0.49 *** 0.409 ***
Neutrophils CD66b (CEACAM8) 0.3 *** 0.29 *** 0.268 *** 0.255 ***
CD11b (ITGAM) 0.101 0.022 0.03 0.5 0.379 *** 0.27 ***
CD15 0.017 0.706 0.001 0.976 0.146 ** 0.123 **
Natural killer cell KIR2DL1 0.213 *** 0.203 *** 0.174 *** 0.128 ***
KIR2DL3 0.081 0.067 0.04 0.375 0.187 *** 0.145 *
KIR3DL1 0.142 * 0.123 * 0.272 *** 0.221 ***
KIR3DL2 0.028 0.533 − 0.024 0.602 0.191 *** 0.135 *
CD56 0.208 *** 0.21 *** 0.211 *** 0.253 ***
CD335 (NKp46) 0.024 0.592 − 0.018 0.694 0.237 *** 0.183 ***
Dendritic cell BDCA-1 (CD1C) 0.415 *** 0.38 *** 0.524 *** 0.446 ***
BDCA-3 (CD141) 0.4 *** 0.363 *** 0.519 *** 0.45 ***
BDCA-4 (NRP1) − 0.017 0.699 − 0.042 0.357 0.257 *** 0.143 **
CD123 0.347 *** 0.308 *** 0.535 *** 0.468 ***
CD11c (ITGAX) 0.137 * 0.071 0.116 0.427 *** 0.319 ***
Th1 T-bet (TBX21) 0.134 * 0.064 0.159 0.365 *** 0.269 ***
STAT4 0.138 * 0.078 0.084 0.431 *** 0.344 ***
STAT1 − 0.204 *** − 0.276 *** 0.026 0.56 -0.059 0.199
Th2 GATA3 − 0.033 0.457 − 0.114 0.012 0.203 *** 0.12 *
STAT6 0.242 *** 0.239 *** 0.123 * 0.111 0.016
IL13 0.148 ** 0.104 0.021 0.235 *** 0.186 ***
Tfh BCL6 0.058 0.189 0.068 0.134 0.075 0.092 0.102 0.025
IL21 − 0.049 0.267 − 0.085 0.061 0.196 *** 0.122 *
Th17 STAT3 0.048 0.275 0.051 0.255 0.072 0.109 0.006 0.89
IL17A 0.063 0.154 0.046 0.307 0.012 0.783 -0.051 0.266
RORγt 0.202 *** 0.242 *** 0.517 *** 0.469 ***
Treg FOXP3 0.003 0.947 − 0.081 0.072 0.281 *** 0.162 **
CD25 − 0.039 0.371 − 0.117 ** 0.293 *** 0.193 ***
CCR8 0.015 0.729 − 0.064 0.155 0.263 *** 0.152 **
STAT5B 0.196 *** 0.18 *** 0.112 0.012 0.095 0.037
T cell exhaustion PD-1 (PDCD1) 0.01 0.816 − 0.065 0.149 0.346 ** 0.249 ***
CTLA4 0.046 0.293 − 0.046 0.31 0.306 *** 0.192 ***
LAG3 − 0.085 0.054 − 0.154 ** 0.17 ** 0.078 0.087
TIM-3 (HAVCR2) 0.098 0.026 0.02 0.652 0.443 *** 0.356 ***
GZMB − 0.089 0.045 − 0.16 ** 0.222 *** 0.116 0.011
  1. ADC, adenocarcinoma; SCC, squamous cell carcinoma; None, correlation without adjustment; Purity, correlation adjusted by purity; TAM, tumor-associated macrophage; Th, T helper cell; Tfh, Follicular helper T cell; Treg, regulatory T cell; Cor, R value of Spearman’s correlation
  2. * P < 0.01; ** P < 0.001; *** P < 0.0001