CLEC3B as a potential diagnostic and prognostic biomarker in lung cancer and association with the immune microenvironment

Sun, Jiaxing; Xie, Tian; Jamal, Muhammad; Tu, Zhenbo; Li, Xinran; Wu, Yingjie; Li, Jingyuan; Zhang, Qiuping; Huang, Xiaoxing

doi:10.1186/s12935-020-01183-1

Table 6 Correlation analysis between CLEC3B and relate genes and markers of immune cells in TIMER

From: CLEC3B as a potential diagnostic and prognostic biomarker in lung cancer and association with the immune microenvironment

Description	Gene markers	ADC				SCC
		None		Purity		None		Purity
		Cor	P	Cor	P	Cor	P	Cor	P
CD8+ T cell	CD8A	0.07	0.113	0.003	0.95	0.322	***	0.238	***
	CD8B	0.08	0.071	0.035	0.438	0.276	***	0.232	***
	CD45	0.2	***	0.126	**	0.447	***	0.361	***
T cell (general)	CD3D	0.138	*	0.066	0.144	0.382	***	0.279	***
	CD3E	0.168	**	0.101	0.024	0.397	***	0.294	***
	CD2	0.155	**	0.083	0.067	0.382	***	0.282	***
B cell	CD19	0.194	***	0.145	*	0.414	***	0.316	***
	CD79A	0.154	**	0.105	0.020	0.385	***	0.279	***
	CD27	0.148	***	0.091	*	0.384	***	0.289	***
	CD20	0.293	***	0.249	***	0.481	***	0.415	***
Monocyte	CD14	0.065	0.139	0	0.994	0.391	***	0.281	***
Monocyte	CD115 (CSF1R)	0.11	0.012	0.04	0.373	0.449	***	0.357	***
TAM	CCL2	0.03	0.5	− 0.036	0.419	0.31	***	0.229	***
	CD68	0.165	**	0.11	0.015	0.372	***	0.27	***
	IL10	0.198	***	0.132	*	0.41	***	0.335	***
M1 Macrophage	INOS (NOS2)	0.236	***	0.23	***	0.11	0.014	0.116	0.011
	CD80	0.101	*	0.021	0.643	0.302	***	0.217	***
	IRF5	0.037	0.4	− 0.021	0.635	0.152	**	0.116	0.011
	IL6	0.02	0.659	− 0.02	0.658	0.203	***	0.154	***
	CD64 (FCGR1A)	0.012	0.792	− 0.069	0.127	0.404	***	0.316	***
M2 Macrophage	CD163	0.098	0.026	0.028	0.529	0.46	***	0.373	***
	CD206	0.306	***	0.256	***	0.456	***	0.374	***
	VSIG4	0.162	**	0.102	0.023	0.478	***	0.4	***
	MS4A4A	0.233	***	0.175	***	0.49	***	0.409	***
Neutrophils	CD66b (CEACAM8)	0.3	***	0.29	***	0.268	***	0.255	***
	CD11b (ITGAM)	0.101	0.022	0.03	0.5	0.379	***	0.27	***
	CD15	0.017	0.706	0.001	0.976	0.146	**	0.123	**
Natural killer cell	KIR2DL1	0.213	***	0.203	***	0.174	***	0.128	***
	KIR2DL3	0.081	0.067	0.04	0.375	0.187	***	0.145	*
	KIR3DL1	0.142	*	0.123	*	0.272	***	0.221	***
	KIR3DL2	0.028	0.533	− 0.024	0.602	0.191	***	0.135	*
	CD56	0.208	***	0.21	***	0.211	***	0.253	***
	CD335 (NKp46)	0.024	0.592	− 0.018	0.694	0.237	***	0.183	***
Dendritic cell	BDCA-1 (CD1C)	0.415	***	0.38	***	0.524	***	0.446	***
	BDCA-3 (CD141)	0.4	***	0.363	***	0.519	***	0.45	***
	BDCA-4 (NRP1)	− 0.017	0.699	− 0.042	0.357	0.257	***	0.143	**
	CD123	0.347	***	0.308	***	0.535	***	0.468	***
	CD11c (ITGAX)	0.137	*	0.071	0.116	0.427	***	0.319	***
Th1	T-bet (TBX21)	0.134	*	0.064	0.159	0.365	***	0.269	***
	STAT4	0.138	*	0.078	0.084	0.431	***	0.344	***
	STAT1	− 0.204	***	− 0.276	***	0.026	0.56	-0.059	0.199
Th2	GATA3	− 0.033	0.457	− 0.114	0.012	0.203	***	0.12	*
	STAT6	0.242	***	0.239	***	0.123	*	0.111	0.016
	IL13	0.148	**	0.104	0.021	0.235	***	0.186	***
Tfh	BCL6	0.058	0.189	0.068	0.134	0.075	0.092	0.102	0.025
Tfh	IL21	− 0.049	0.267	− 0.085	0.061	0.196	***	0.122	*
Th17	STAT3	0.048	0.275	0.051	0.255	0.072	0.109	0.006	0.89
	IL17A	0.063	0.154	0.046	0.307	0.012	0.783	-0.051	0.266
	RORγt	0.202	***	0.242	***	0.517	***	0.469	***
Treg	FOXP3	0.003	0.947	− 0.081	0.072	0.281	***	0.162	**
	CD25	− 0.039	0.371	− 0.117	**	0.293	***	0.193	***
	CCR8	0.015	0.729	− 0.064	0.155	0.263	***	0.152	**
	STAT5B	0.196	***	0.18	***	0.112	0.012	0.095	0.037
T cell exhaustion	PD-1 (PDCD1)	0.01	0.816	− 0.065	0.149	0.346	**	0.249	***
	CTLA4	0.046	0.293	− 0.046	0.31	0.306	***	0.192	***
	LAG3	− 0.085	0.054	− 0.154	**	0.17	**	0.078	0.087
	TIM-3 (HAVCR2)	0.098	0.026	0.02	0.652	0.443	***	0.356	***
	GZMB	− 0.089	0.045	− 0.16	**	0.222	***	0.116	0.011

ADC, adenocarcinoma; SCC, squamous cell carcinoma; None, correlation without adjustment; Purity, correlation adjusted by purity; TAM, tumor-associated macrophage; Th, T helper cell; Tfh, Follicular helper T cell; Treg, regulatory T cell; Cor, R value of Spearman’s correlation
* P < 0.01; ** P < 0.001; *** P < 0.0001

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