Table 1 Pathological scoring criteria of HE staining in mouse colon
Score | Inflammation severity | Tumor pathological | |||
|---|---|---|---|---|---|
Pattern of leukocyte infiltration | Degree of leukocyte infiltration | Number of infiltrated leukocytes | Classification of lesion severity | Histological typing | |
1 point | Increased lymphoid aggregation | Infiltration confined to the mucosa | Small amount | Intraepithelial neoplasia (nuclear floating does not exceed 3/4 of the total epithelial height) | Highly differentiated adenocarcinoma (> 95% duct formation) |
2 point | Cryptitis (neutrophils in the intestinal crypt epithelium) | Infiltration in the submucosa | Medium | Intramucosal carcinoma (disrupted gland structures, with a shared gland wall and a sieve-like structure, without penetrating the mucosal muscle layer) | Moderately differentiated adenocarcinoma (50–95% duct formation) |
3 point | Crypt abscess (neutrophils accumulate in the crypt cavity, sometimes showing crypt rupture)/ | Infiltration of the whole layer | Severe | Tubular adenocarcinoma (tumor cells penetrating the mucosal muscle layer) | Poorly differentiated adenocarcinoma (0-49% duct formation) |
4 point | Â | Â | Â | Â | Undifferentiated carcinoma |