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Fig. 4 | Cancer Cell International

Fig. 4

From: MicroRNA-122-5p inhibits cell proliferation, migration and invasion by targeting CCNG1 in pancreatic ductal adenocarcinoma

Fig. 4

CCNG1 was upregulated in PDAC tissues and cells and was verified to be a direct target of miR-122-5p. a The predicted target site of miR-122-5p on 3′-UTR of CCNG1 mRNA. b 60 pairs of human PDAC tissues and paired normal tissues were collected to detect the relative expression of CCNG1 by qRT-PCR. c Immunohistochemistry analysis of CCNG1 expression in human PDAC tissue and paired normal tissue. d The correlation between the expression levels of miR-122-5p and CCNG1. e The relative expression of CCNG1 was determined in PDAC cells compared to HPDE6-C7 cells. f, g Effects of highly expressed miR-122-5p on the expression of CCNG1 in PDAC cells were verified by western blot and qRT-PCR. h Effects of miR-122-5p overexpression on the luciferase activity in HEK293T cells (*P < 0.05)

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Cancer Cell International

ISSN: 1475-2867

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