Fig. 9

Schematic representation of proposed mechanism of action of miR-122-5p induced G0/G1 phase arrest and apoptosis as well as inhibition of migration and invasion in pancreatic cancer cells. Upregulation of miR-122-5p caused G0/G1 phase arrest by decreasing the levels of Cyclin E and CDK2 and enhancing the expression of p21 and p27 in both cell lines. MiR-122-5p also leaded to apoptosis via Bcl-2 and Bax. Overexpression of miR-122-5p could suppress EMT by dramatically increasing the expression of E-cadherin, while decreasing the expression of Vimentin, N-cadherin and MMP9. Furthermore, miR-122-5p exerted anticancer effects by directly targeting CCNG1