Table 1 Basic characteristics of the studies included for meta-analysis
From: A pooled analysis of the prognostic value of PD-L1 in melanoma: evidence from 1062 patients
Study | Year | Country | Sample size | Ethnicity | Age | Stage | Treatment | Study duration | Sampling | Detection method | Survival outcomes | Types of analysis | Cut-off value | Study design | Follow-up (month) | NOS score |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cho | 2016 | Korea | 37 | Asian | 58 (21–81) | Metastatic | ICIs | Jan-Dec, 2015 | Tissue | IHC | PFS | Univariate | > 5% | Retrospective | 6.4 (1.4–11.2) | 8 |
Gadiot | 2011 | The Netherlands | 63 | Caucasian | 53 (18–91) | Metastatic | Mixed | 2000–2004 | Tissue | IHC | OS | Univariate | > 1% | Retrospective | 51.2 (6.8–134.8) | 9 |
Johnson | 2018 | USA | 142 | Caucasian | 63.4 | Metastatic | ICIs | 2010–2016 | Tissue | IHC | OS, PFS | Univariate | > 5% | Retrospective | NA | 8 |
Madonna | 2018 | Italy | 114 | Caucasian | 61 (25–90) | Metastatic | ICIs | 2010–2013 | Tissue | IHC | OS | Univariate | > 5% | Retrospective | NA | 7 |
Madore | 2015 | Australia | 58 | Caucasian | 61 | Mixed | Mixed | NA | Tissue | IHC | PFS | Univariate | > 1% | Retrospective | 49.2 (4.1–229.2) | 9 |
Massi | 2015 | Italy | 80 | Caucasian | 56 (21–82) | Metastatic | BRAFi | 2011–2014 | Tissue | IHC | OS, PFS | Univariate | > 5% | Retrospective | 9 | 7 |
Morrison | 2018 | USA | 137 | Caucasian | 61 | Metastatic | ICIs | 1990–2016 | Tissue | IHC | OS | Univariate | > 1% | Prospective | 16.2 | 8 |
Obeid | 2016 | USA | 147 | Caucasian | 58.9 | Metastatic | Mixed | 1982–2007 | Tissue | IHC | OS | Univariate | > 5% | Retrospective | 1–358 | 8 |
Ren | 2018 | China | 78 | Asian | 61.5 (31–85) | Mixed | Surgery | 2005–2012 | Tissue | IHC | PFS | Multivariate | H-score > 5 | Retrospective | 73.5 (60–151) | 8 |
Ren | 2019 | China | 89 | Asian | 63 (40–90) | Mixed | Surgery | 2010–2017 | Tissue | IHC | OS, PFS | Univariate | > 5% | Retrospective | NA | 7 |
Schaper-Gerhardt | 2018 | Germany | 58 | Caucasian | 61 (27–88) | Metastatic | BRAFi | NA | Tissue | IHC | OS, PFS | Univariate | > 1% | Prospective | 10.3 (0.6–36.3) | 8 |
Thierauf | 2015 | Germany | 23 | Caucasian | 66 | Mixed | Surgery | NA | Tissue | IHC | OS, PFS | Univariate | > Score 1 | Retrospective | NA | 6 |
Wang | 2019 | China | 36 | Asian | 48 (27–77) | Mixed | Mixed | 2004–2018 | Tissue | IHC | OS | Univariate | > 1% | Retrospective | NA | 7 |