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Fig. 6 | Cancer Cell International

Fig. 6

From: Tenascin-C predicts poor outcomes for patients with colorectal cancer and drives cancer stemness via Hedgehog signaling pathway

Fig. 6

Hedgehog/SMO/GLI1 signaling plays an essential role for targeted activation of Tenascin-C (TNC) in colorectal cancer (CRC). a Immunohistochemical staining of SMO, GLI1 and TNC in CRC tissues (original magnification ×200). Scale bar represented 100 μm. b, c Immunofluorescence staining for GLI1 and TNC in the HT29 and HCT116 cell lines. Blue for DAP1; green for GLI1; red for TNC; double labeling for Merge. d, e Protein expression of GLI1 and TNC after treatment with DMSO and 20 μM GLI1 inhibitor GANT61 (GAN) in HT29 and HCT116 cells, respectively. Western blotting data were normalized to those for β-actin and expressed as fold changes relative to levels in the control group. **P < 0.01, ***P < 0.001 versus control

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Cancer Cell International

ISSN: 1475-2867

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