Fig. 3
From: Mesenchymal stem cells: a promising way in therapies of graft-versus-host disease
The mechanism of combination of CXCL-5 and anti-CCL24. The potential mechanism lies in the synergy between CXCL5 and anti-CCL24 antibody (2FC). In vivo, 2FC could decrease not only transplanted Th 1 and Th 17 but also cytotoxic T lymphocytes and natural killer cells to increase immunosuppressive neutrophils without affecting human hematopoietic stem cell reconstitution. What’s more, it attenuates the secretion of FN-γ, IL-6, IL-17A, IL-8, macrophage inflammatory protein-1β, and monocyte chemoattractant protein-1. CXCL-5,Chemokine (C–X–C motif) ligand 5;Anti-CCL24, chemokine (C–C motif) ligand 24; Th, T helper cells; CTL, Cytotoxic T lymphocyte; NK cells, natural killer T cells; MIP-1β, macrophage inflammatory protein-1β; MCP-1, monocyte chemoattractant protein-1