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Table 3 Expression pattern of MIR31HG in cancers and its interaction with miRNAs and target genes

From: The predictive value of lncRNA MIR31HG expression on clinical outcomes in patients with solid malignant tumors

Tumor type

Expression

Signaling pathways

MiRNAs and target genes

Biological functions

References

Osteosarcoma

/

miR-361, VEGF, FOXM1, Twist

Cell proliferation, migration, apoptosis, G1/G arrest, EMT

[14]

Chordoma

/

miR-31, EZH2, RNF144B

Cell proliferation, migration, invasion, EMT

[15]

OSCC

/

HIF-1α, p300

Sphere-forming ability, metabolic shift and metastasis

[4]

HNSCC/LSCC

/

HIF-1α, p21

Cell proliferation, cell cycle progression, apoptosis

[35]

LSCC

/

miR-31, RhoA

Cell growth, cell cycle, invasion

[42]

Breast cancer

/

/

Cell proliferation, apoptosis, migration, invasion

[12]

Cervical cancer

/

/

Cell proliferation, apoptosis

[27]

VSCC

/

/

/

[28]

NSCLC

Wnt/β-catenin

GSK3β, Twist1, Vimentin, E-cadherin

Cell proliferation, invasion, EMT

[2]

NSCLC

PI3K/Akt

EGFR

Cell proliferation, apoptosis, G0/G1 arrest, gefitinib resistance

[19]

NSCLC

RAF/MEK/ERK, PI3K/Akt

miR-31, FIH-1, RASA1

Cell proliferation, clonogenic growth, gefitinib resistance

[43]

NSCLC

/

miR-214

Cell migration, invasion

[40]

LUAD

/

/

Cell proliferation, cell cycle arrest

[22]

PDAC

/

miR-193b, CCND1, Mcl-1, NT5E, KRAS, uPA, ETS1

Cell growth, apoptosis, G1/S arrest, invasion

[6]

ESCC

/

Furin, MMP1

Cell proliferation, migration, invasion

[29]

ESCC

/

/

/

[30]

Gastric cancer

/

p21, E-cadherin

Cell proliferation, migration

[33]

Gastric cancer

/

E2F1

Cell proliferation

[24]

CRC

/

miR-31-5p, MYC, TNF-α/NF-κB, TGF-β, IFN-α/γ

EMT

[16]

CRC

/

/

Cell proliferation, apoptosis

[18]

HCC

/

miR-575, ST7L

Cell proliferation, metastasis

[5]

Bladder cancer

/

/

/

[25]

  1. Akt protein kinase B, CCND1 cyclin D1, CRC, colorectal cancer, E2F1, E2F transcription factor 1, EGFR epidermal growth factor receptor, EMT Epithelial-mesenchymal transition, ERK extracellular regulated protein kinases, ESCC esophageal squamous cell carcinoma, ETS1, ETS proto-oncogene 1, transcription factor, EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit, FIH-1 hypoxia inducible factor 1 subunit alpha inhibitor, FOXM1 forkhead box M1, GSK-3β glycogen synthase kinase-3β, HCC hepatocellular carcinoma, HIF-1α hypoxia inducible factor 1 subunit alpha, HNSCC head and neck squamous cell carcinoma, IFN-α/γ interferon-α/γ, LSCC laryngeal squamous cell cancer, LUAD lung adenocarcinoma, MMP1 matrix metallopeptidase 1, NSCLC Non–small cell lung cancer, NT5E 5′-nucleotidase ecto, OSCC oral squamous cell carcinoma, PDAC pancreatic ductal adenocarcinoma, PI3K phosphoinositide 3-kinase, RASA1 RAS p21 protein activator 1, RhoA ras homolog gene family, member A, ST7L suppression of tumorigenicity 7 like, TGF-β transforming growth factor-β, TNF tumor necrosis factor, VEGF vascular endothelial growth factor, VSCC vulvar squamous cell carcinoma
  2. ↑up-regulated, ↓down-regulated