The predictive value of lncRNA MIR31HG expression on clinical outcomes in patients with solid malignant tumors

Table 3 Expression pattern of MIR31HG in cancers and its interaction with miRNAs and target genes

Tumor type	Expression	Signaling pathways	MiRNAs and target genes	Biological functions	References
Osteosarcoma	↑	/	miR-361, VEGF, FOXM1, Twist	Cell proliferation, migration, apoptosis, G1/G arrest, EMT	[14]
Chordoma	↑	/	miR-31, EZH2, RNF144B	Cell proliferation, migration, invasion, EMT	[15]
OSCC	↑	/	HIF-1α, p300	Sphere-forming ability, metabolic shift and metastasis	[4]
HNSCC/LSCC	↑	/	HIF-1α, p21	Cell proliferation, cell cycle progression, apoptosis	[35]
LSCC	↑	/	miR-31, RhoA	Cell growth, cell cycle, invasion	[42]
Breast cancer	↑	/	/	Cell proliferation, apoptosis, migration, invasion	[12]
Cervical cancer	↑	/	/	Cell proliferation, apoptosis	[27]
VSCC	↑	/	/	/	[28]
NSCLC	↑	Wnt/β-catenin	GSK3β, Twist1, Vimentin, E-cadherin	Cell proliferation, invasion, EMT	[2]
NSCLC	↑	PI3K/Akt	EGFR	Cell proliferation, apoptosis, G0/G1 arrest, gefitinib resistance	[19]
NSCLC	↑	RAF/MEK/ERK, PI3K/Akt	miR-31, FIH-1, RASA1	Cell proliferation, clonogenic growth, gefitinib resistance	[43]
NSCLC	↑	/	miR-214	Cell migration, invasion	[40]
LUAD	↑	/	/	Cell proliferation, cell cycle arrest	[22]
PDAC	↑	/	miR-193b, CCND1, Mcl-1, NT5E, KRAS, uPA, ETS1	Cell growth, apoptosis, G1/S arrest, invasion	[6]
ESCC	↑	/	Furin, MMP1	Cell proliferation, migration, invasion	[29]
ESCC	↓	/	/	/	[30]
Gastric cancer	↑	/	p21, E-cadherin	Cell proliferation, migration	[33]
Gastric cancer	↓	/	E2F1	Cell proliferation	[24]
CRC	↑	/	miR-31-5p, MYC, TNF-α/NF-κB, TGF-β, IFN-α/γ	EMT	[16]
CRC	↓	/	/	Cell proliferation, apoptosis	[18]
HCC	↓	/	miR-575, ST7L	Cell proliferation, metastasis	[5]
Bladder cancer	↓	/	/	/	[25]

Akt protein kinase B, CCND1 cyclin D1, CRC, colorectal cancer, E2F1, E2F transcription factor 1, EGFR epidermal growth factor receptor, EMT Epithelial-mesenchymal transition, ERK extracellular regulated protein kinases, ESCC esophageal squamous cell carcinoma, ETS1, ETS proto-oncogene 1, transcription factor, EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit, FIH-1 hypoxia inducible factor 1 subunit alpha inhibitor, FOXM1 forkhead box M1, GSK-3β glycogen synthase kinase-3β, HCC hepatocellular carcinoma, HIF-1α hypoxia inducible factor 1 subunit alpha, HNSCC head and neck squamous cell carcinoma, IFN-α/γ interferon-α/γ, LSCC laryngeal squamous cell cancer, LUAD lung adenocarcinoma, MMP1 matrix metallopeptidase 1, NSCLC Non–small cell lung cancer, NT5E 5′-nucleotidase ecto, OSCC oral squamous cell carcinoma, PDAC pancreatic ductal adenocarcinoma, PI3K phosphoinositide 3-kinase, RASA1 RAS p21 protein activator 1, RhoA ras homolog gene family, member A, ST7L suppression of tumorigenicity 7 like, TGF-β transforming growth factor-β, TNF tumor necrosis factor, VEGF vascular endothelial growth factor, VSCC vulvar squamous cell carcinoma
↑up-regulated, ↓down-regulated

ISSN: 1475-2867