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Table 3 Expression pattern of MIR31HG in cancers and its interaction with miRNAs and target genes

From: The predictive value of lncRNA MIR31HG expression on clinical outcomes in patients with solid malignant tumors

Tumor type Expression Signaling pathways MiRNAs and target genes Biological functions References
Osteosarcoma / miR-361, VEGF, FOXM1, Twist Cell proliferation, migration, apoptosis, G1/G arrest, EMT [14]
Chordoma / miR-31, EZH2, RNF144B Cell proliferation, migration, invasion, EMT [15]
OSCC / HIF-1α, p300 Sphere-forming ability, metabolic shift and metastasis [4]
HNSCC/LSCC / HIF-1α, p21 Cell proliferation, cell cycle progression, apoptosis [35]
LSCC / miR-31, RhoA Cell growth, cell cycle, invasion [42]
Breast cancer / / Cell proliferation, apoptosis, migration, invasion [12]
Cervical cancer / / Cell proliferation, apoptosis [27]
VSCC / / / [28]
NSCLC Wnt/β-catenin GSK3β, Twist1, Vimentin, E-cadherin Cell proliferation, invasion, EMT [2]
NSCLC PI3K/Akt EGFR Cell proliferation, apoptosis, G0/G1 arrest, gefitinib resistance [19]
NSCLC RAF/MEK/ERK, PI3K/Akt miR-31, FIH-1, RASA1 Cell proliferation, clonogenic growth, gefitinib resistance [43]
NSCLC / miR-214 Cell migration, invasion [40]
LUAD / / Cell proliferation, cell cycle arrest [22]
PDAC / miR-193b, CCND1, Mcl-1, NT5E, KRAS, uPA, ETS1 Cell growth, apoptosis, G1/S arrest, invasion [6]
ESCC / Furin, MMP1 Cell proliferation, migration, invasion [29]
ESCC / / / [30]
Gastric cancer / p21, E-cadherin Cell proliferation, migration [33]
Gastric cancer / E2F1 Cell proliferation [24]
CRC / miR-31-5p, MYC, TNF-α/NF-κB, TGF-β, IFN-α/γ EMT [16]
CRC / / Cell proliferation, apoptosis [18]
HCC / miR-575, ST7L Cell proliferation, metastasis [5]
Bladder cancer / / / [25]
  1. Akt protein kinase B, CCND1 cyclin D1, CRC, colorectal cancer, E2F1, E2F transcription factor 1, EGFR epidermal growth factor receptor, EMT Epithelial-mesenchymal transition, ERK extracellular regulated protein kinases, ESCC esophageal squamous cell carcinoma, ETS1, ETS proto-oncogene 1, transcription factor, EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit, FIH-1 hypoxia inducible factor 1 subunit alpha inhibitor, FOXM1 forkhead box M1, GSK-3β glycogen synthase kinase-3β, HCC hepatocellular carcinoma, HIF-1α hypoxia inducible factor 1 subunit alpha, HNSCC head and neck squamous cell carcinoma, IFN-α/γ interferon-α/γ, LSCC laryngeal squamous cell cancer, LUAD lung adenocarcinoma, MMP1 matrix metallopeptidase 1, NSCLC Non–small cell lung cancer, NT5E 5′-nucleotidase ecto, OSCC oral squamous cell carcinoma, PDAC pancreatic ductal adenocarcinoma, PI3K phosphoinositide 3-kinase, RASA1 RAS p21 protein activator 1, RhoA ras homolog gene family, member A, ST7L suppression of tumorigenicity 7 like, TGF-β transforming growth factor-β, TNF tumor necrosis factor, VEGF vascular endothelial growth factor, VSCC vulvar squamous cell carcinoma
  2. ↑up-regulated, ↓down-regulated