Fig. 1
From: The yin and yang functions of extracellular ATP and adenosine in tumor immunity
Tissue damage, cellular stress, hypoxia, acute and chronic inflammation, platelet aggregation and anticancer therapies induce tumor cells death and metabolic changes, leading to the increased concentrations of extracellular ATP (eATP) and adenosine (ADO) in tumor microenvironment (TME) (3 to 10 mM). eATP communicates with components of TME to play the immune-activating functions, including monocytes (Mo)/macrophages (Mø), dendritic cells, T lymphocytes, eosinophils, neutrophils and B cells