Fig. 3
From: Insight into the role of p62 in the cisplatin resistant mechanisms of ovarian cancer
Pro-survival signaling regulation by p62 in ovarian cancer cells. a Highly expressed p62 activates NF-κB through RIP1 and TRAF6. p62 also competes with Nrf2 for binding to Keap1, which promotes the transcriptional activity of Nrf2. b p62 is recruited to function in PINK1/Parkin-mediated mitophagy; p62 may also be involved in regulation of the PGAM5-Keap1-Nrf2 complex, which is responsible for mitochondrial dynamics