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Fig. 1 | Cancer Cell International

Fig. 1

From: Novel monoclonal antibodies against thymidine kinase 1 and their potential use for the immunotargeting of lung, breast and colon cancer cells

Fig. 1

a Alignment of the amino acid sequences of thymidine kinase 1 from 4 different species, Canis lupus familiaris, Oryctolagus cuniculus, Mus musculus and Homo sapiens. The conserved regions are highlighted and the differences between species are shown in the identity top bar. TK1 epitopes are annotated in yellow. b The tetrameric form of TK1 was 3D modeled using the PyMOL software and the 1XBT crystal structure from the NCBI protein data bank. The Peptide sequences utilized in the generation of monoclonal antibodies were highlighted in red. The epitopes selected for antibody generation were all peptide sequences that were exposed and hypothetically accessible to antibody binding. Epitope 6 is localized at the end of the C-terminus of the TK1 molecule but not visible in the available crystal structures of TK1

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Cancer Cell International

ISSN: 1475-2867

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