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Fig. 10 | Cancer Cell International

Fig. 10

From: Novel monoclonal antibodies against thymidine kinase 1 and their potential use for the immunotargeting of lung, breast and colon cancer cells

Fig. 10

ADCC assay using TK1-specific monoclonal antibodies 3B4 and 8G2. MNC and A549 cells were co-cultured in the presence or absence of the TK1 monoclonal antibodies 3B4 and 8G2. a On the left a 3B4 antibody concentration dose–response curve can be observed. The ADCC response started after 24 h of treatment. c, e A significant cytolysis percentage is observed at 36 h with a 7.5 μg/ml 3B4 antibody (p = 0.0001). Graph b on the right show a dose–response curve for antibody 8G2. d, f. A significant increase in the cytolysis percentage compared to the isotype controls (p = 0.0003) was observed at 48 h with a 2.5 μg/ml antibody concentration

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Cancer Cell International

ISSN: 1475-2867

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