Skip to main content
Fig. 1 | Cancer Cell International

Fig. 1

From: Lattice complex assembled by noncompetitive anti-EGFR antibodies regulates actin cytoskeletal reorganization

Fig. 1

Lattice complex assembled by EGFR and its different antibody combinations on cell membrane. ac Different single antibody (40 nM) or combination of antibodies (20 nM each antibody) was treated on Hela cells for 1 h. Bars, 10 μm. d The lattice complex formed by EGFR and its noncompetitive antibodies on cell membrane when two EGFR antibodies with noncompetitive epitopes were treated on Hela cells. e The EGFR pattern with two competitive antibodies on Hela cells. f EGFR-antibody complex formed on cell membrane by single antibody. g, i Different single antibody (40 nM) or combination of antibodies (20 nM each antibody) was treated on Hela cells for 10 min, cell nuclei were dyed by Hoechst 33342 (blue). Arrowheads showed the lattice complex. Bars, 10 μm. j 20 nM Cetuximab (green) and 20 nM H11 (red) were treated on Hela cells for 10 min. Arrowheads showed the lattice complex. Surface rendering was generated from Imaris software. Bars in left 2 columns, 10 μm; in right 1 column, 1 μm

Back to article page