Fig. 6

GALNT7 promotes cell proliferation and invasion by activating EGFR/PI3K/AKT pathway. HeLa and Caski cells were transfected with Vector, pcDNA-GALNT7, or treated with 10 μM PD153035 and transfected with Vector or pcDNA-GALNT7, or treated with 10 μM LY294002 and transfected with Vector or pcDNA-GALNT7 for 24 h. a, b Cell proliferation was detected using CCK-8 assay after transfection for 72 h. c, d Transwell invasion assay was used to evaluate the invasion capacity after transfection for 24 h. e, f western blot analysis was used to detect the protein expression levels of GALNT7, EGFR, PI3K, p-PI3K, AKT, p-AKT after transfection for 24 h in HeLa and Caski cells, respectively. *P < 0.05, **P < 0.01