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Fig. 2 | Cancer Cell International

Fig. 2

From: LncRNA IGBP1-AS1/miR-24-1/ZIC3 loop regulates the proliferation and invasion ability in breast cancer

Fig. 2

In-vitro inhibitory effect of the IGBP1-AS1 on BC cell proliferation. a The RT-qPCR indicated the expression of IGBP1-AS1 in BC cell lines (HCC70 and UACC-812) relative to human mammary cells (76N-F2V). b The RT-qPCR demonstrated up-regulated efficiency of IGBP1-AS1 in BC cells. **P value < 0.01. c, d Assessment of cell proliferation and viability by CCK8 and MTT assays. *P value < 0.01. e The FACS analysis indicated overexpression of IGBP1-AS1 may reduce the number of cells in the G2/M phase. *P value < 0.01. f Increased expression level of IGBP1-AS1 could promote the apoptosis of BC cells according to the Annexin V assay. **P value < 0.01. g, h The results of the transwell assay and wound-healing assay performed with HCC70 and UACC-812 cells transfected with Lv-IGBP1-AS1 or Lv-NC. **P value < 0.01 vs. control. i The expression level of IGBP1-AS1 in BC tissues and adjacent normal tissues according to the ISH assay. j, k Comparison of the Kaplan–Meier curves of the BC patients with respect to OS rate and PFS rate respectively

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