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Table 4 Multivariate logistic regression analysis of SNPs

From: Single-nucleotide polymorphism rs17548629 in RIPK1 gene may be associated with lung cancer in a young and middle-aged Han Chinese population

  Sort Squamous cell carcinoma Adenocarcinoma Small cell carcinoma Total lung cancer
Cs/cnt OR (95% CI)Δ Cs/cnt OR (95% CI)Δ Cs/cnt OR (95% CI)Δ Cs/cnt OR (95% CI)Δ
rs17548629
 Codominant CC 72/323 1.000 154/323 1.000 27/323 1.000 309/323 1.000
CT 57/247 1.022 (0.666–1.567) 105/247 0.828 (0.598–1.146) 14/247 0.648 (0.321–1.307) 210/247 0.835 (0.634–1.099)
TT 11/39 1.569 (0.704–3.496) 26/39 1.634 (0.915–2.919) 6/39 2.317 (0.822–6.532) 52/39 1.671 (1.010–2.766)*
 Dominant CC 72/323 1.000 154/323 1.000 27/323 1.000 309/323 1.000
CT + TT 68/286 1.094 (0.728–1.645) 131/286 0.928 (0.683–1.262) 20/286 0.837 (0.445–1.577) 262/286 0.937 (0.722–1.216)
 Super-dominant CC + TT 83/362 1.000 180/362 1.000 33/362 1.000 361/362 1.000
CT 57/247 0.968 (0.639–1.468) 105/247 0.778 (0.567–1.067) 14/247 0.580 (0.293–1.146) 210/247 0.782 (0.599–1.023)
 Recessive CC + CT 129/570 1.000 259/570 1.000 41/570 1.000 519/570 1.000
TT 11/39 1.556 (0.713–3.394) 26/39 1.769 (1.007–3.109)* 6/39 2.734 (0.997–7.497) 52/39 1.803 (1.104–2.944)*
 Additive    1.140 (0.828–1.569)   1.057 (0.830–1.346)   1.093 (0.668–1.788)   1.066 (0.869–1.308)
rs77736895
 Codominant CC 122/523 1.000 252/523 1.000 39/523 1.000 492/523 1.000
CT 17/84 0.938 (0.511–1.722) 33/84 0.822 (0.516–1.309) 8/84 1.397 (0.599–3.256) 77/84 1.000 (0.686–1.457)
TT 1/2 2.650 (0.126–55.587) 0/2 0/2 2/2 1.446 (0.112–18.728)
 Dominant CC 122/523 1.000 252/523 1.000 39/523 1.000 492/523 1.000
CT + TT 18/86 0.971 (0.535–1.762) 33/86 0.809 (0.509–1.288) 8/86 1.390 (0.597–3.239) 79/86 1.006 (0.692–1.463)
 Super-dominant CC + TT 123/525 1.000 252/525 1.000 39/525 1.000 494/525 1.000
CT 17/84 0.934 (0.509–1.714) 33/84 0.824 (0.517–1.312) 8/84 1.400 (0.601–3.263) 77/84 0.999 (0.685–1.455)
 Recessive CT + CC 139/607 1.000 285/607 1.000 47/607 1.000 569/607 1.000
TT 1/2 2.672 (0.127–56.085) 0/2 0/2 2/2 1.446 (0.112–18.719)
 Additive    1.009 (0.570–1.784)   0.802 (0.509–1.266)   1.366 (0.595–3.133)   1.013 (0.704–1.458)
  1. Cs/cnt, case/control
  2. Co-dominant, TT VS CT VS CC; Dominant (CT + TT) VS CC; Super-dominant, (CC + TT) VS CT; Recessive, TT VS (CC + CT); Additive, TT VS CC
  3. p < 0.05
  4. ΔORs were adjusted for demographic characteristics (age, gender, marital status, and education level) and environmental factors (intake of food, drinking tea, alcohol consumption, living environment, smoking, passive smoking, history of lung diseases, occupational history, family history of cancer, body mass index and physical activity)