Fig. 3
From: Role of cancer stem cells in the development of giant cell tumor of bone
Human embryonic stem cells (hESCs) and other normal stem cells like; adult stem cells shown in the figure may lead to the development of normal stem cell progeny as well as other tissues normally, but when mutated, it leads to uncontrollable hierarchy giving birth to enormous cell types with mutations forming huge mass/colonies at metastasis stage considered as cancer stem cells (CSCs). Monoclonal antibodies (MAbs) could be present in cancer stem cells at high level which can be highly specific to embryonic stem cells and play a marvelous role in the identification of suitable surface biomarkers for cancer stem cells