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Fig. 2 | Cancer Cell International

Fig. 2

From: FENDRR suppresses cervical cancer proliferation and invasion by targeting miR-15a/b-5p and regulating TUBA1A expression

Fig. 2

FENDRR interacts with miR-15a/b-5p. a Nuclear and cytoplasmic fraction RNA analysis. b 7 miRNAs selected with binding sites to FENDRR by informatics analysis. c Relative expression of the 7 selected miRNAs in adjacent normal tissues and tumor tissues. d MiRNA expression after overexpressing FENDRR. e MiR-15a-5p and miR-15b-5p knockdown efficiency test. fi Cell proliferation, apoptosis, migration and invasion and EMT process change after knockdown of miR-15a-5p and miR-15b-5p were detected by colony formation assay, flow cytometry assay, transwell assays and western blot. j RIP assay verified the coexistence of indicated RNA molecules in RISC. k Luciferase reporter assay demonstrated the binding potential between FENDRR and miR-15a/b-5p. **p < 0.01; n.s. not significant

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