Table 1 Effect of fucoidan on colon cancer cells in vitro
From: The anti-cancer effects of fucoidan: a review of both in vivo and in vitro investigations
Cell Type | Fucoidan source | Dose (μg/mL) | Effects on cell cycle | Effects on apopotosis pathways | Action characteristic | Action mechanism | Ref |
|---|---|---|---|---|---|---|---|
DLD-1 | Saccharina | 50 | – | – |  Inhibit the binding of EGF receptor with EGF | Inhibit cell proliferation | [47] |
DLD-1 | Sargassum | 100 | – | – | Less cytotoxic colony formation inhibition | Inhibit cell proliferation | [48] |
HT-29 HCT-116 | Fucus vesiculosus | 20 | – | Caspase-8, 9, 7, 3 activation PARP, Bak, Bid, Fas ↑ Mcl-1, survivin, XIAP↓ | – |  Induce cell apoptosis | [40] |
WiDr LoVo | Undaria pinnatifida | 200–1000 | – | – | Less cytotoxic | Inhibit cell proliferation | [18] |
HT-29 | Fucus vesiculosus | 0–1000 | – | IRS-1/PI3K/AKT pathway-related proteins↓ Ras/Raf/ERK pathway-related proteins ↓ | – | Inhibit cell proliferation Induce cell apoptosis | [49] |