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Table 1 Effect of fucoidan on colon cancer cells in vitro

From: The anti-cancer effects of fucoidan: a review of both in vivo and in vitro investigations

Cell TypeFucoidan sourceDose (μg/mL)Effects on cell cycleEffects on apopotosis pathwaysAction characteristicAction mechanismRef
DLD-1Saccharina50 Inhibit the binding of EGF receptor with EGFInhibit cell proliferation[47]
DLD-1Sargassum100Less cytotoxic colony formation inhibitionInhibit cell proliferation[48]
HT-29
HCT-116
Fucus vesiculosus20Caspase-8, 9, 7, 3 activation
PARP, Bak, Bid, Fas ↑
Mcl-1, survivin, XIAP↓
 Induce cell apoptosis[40]
WiDr
LoVo
Undaria pinnatifida200–1000Less cytotoxicInhibit cell proliferation[18]
HT-29Fucus vesiculosus0–1000IRS-1/PI3K/AKT pathway-related proteins↓
Ras/Raf/ERK pathway-related proteins ↓
Inhibit cell proliferation
Induce cell apoptosis
[49]
  1. EGF epidermal growth factor, PARP poly(ADP-ribose) polymerase, XIAP X-linked inhibitor of apoptosis protein