Table 2 Effect of fucoidan on breast cancer cells in vitro
From: The anti-cancer effects of fucoidan: a review of both in vivo and in vitro investigations
Cell type | Fucoidan source | Dose (μg/mL) | Effects on cell cycle | Effects on apopotosis pathways | Action characteristic | Action mechanism | Ref |
|---|---|---|---|---|---|---|---|
MCF-7 | Cladosiphon | 1000 | Sub-G1 fraction↑ | PARP cleavage Caspase-7,8,9 ↑ Cytochrome C, Bax, Bid↑ | – | Induce cell apoptosis | [50] |
T-47D | Saccharina | 50 | – | – | Less cytotoxic inhibit the binding of EGFReceptor  with EGF | Inhibit cell proliferation | [47] |
MCF-7 | Fucus vesiculosus | 300 | G1 phase arrest Sub-G1 fraction↑ Cyclin D1, CDK-4 gene expression↓ | Caspase-8 activation Cytochrome C, Bax ↑ Bcl-2↓ Release of APAf-1↑ | ROS↑ | Induce cell apoptosis | [51] |
MDA-MB-231 | Fucus vesiculosus | 90–120 | – | The protein expressionof phosphorylated Smad2/3, Smad4↓ | – | Inhibit cell proliferation | [22] |
MCF-7 | Undaria pinnatifida | 2004–1000 | – | – | – | Inhibit cell proliferation | [18] |