Table 3 Effect of fucoidan on lung cancer cells in vitro
From: The anti-cancer effects of fucoidan: a review of both in vivo and in vitro investigations
Cell type | Fucoidan source | Dose (μg/mL) | Effects on cell cycle | Effects on apopotosis pathways | Action characteristic | Action mechanism | Ref |
|---|---|---|---|---|---|---|---|
A549 | Undaria pinnatifida | 10–200 | sub-G1 fraction↑ | Bcl-2, p38, Phospho-PI3K/Akt, procaspase-3↓ Bax, caspase-9, Phospho-ERK1/2 ↑ PARP cleavage | NK-cell ↑ | Inhibit cell proliferation Induce cell apoptosis | [53] |
NSCLC-N6 | Bifurcaria bifurcata | 2–9 | G1 phase arrest | – | The growth arrest is irreversible | Inhibit cell proliferation | [52] |
Lewis lung carcinoma cells | Fucus vesiculosus | 50–400 | – | NF-κB↓ | Inhibit VEGF,MMPs | Inhibit metastasis | [41] |
A549 | Undaria pinnatifida | 200–1000 | – | – | Less cytotoxic | Inhibit cell proliferation | [18] |
A549 H1975 | Fucus vesiculosus | 0–400 | – | Caspase-3↑ PARP cleavage | TLR-4 mediated | Inhibit cell proliferation Induce cell apoptosis | [17] |
A549 | Turbinaria conoides | 10–1000 | G0/G1 phase arrest | – | – | Inhibit cell proliferation Induce cell apoptosis | [45] |