Table 4 Effect of fucoidan on hepatoma carcinoma cells in vitro
From: The anti-cancer effects of fucoidan: a review of both in vivo and in vitro investigations
Cell type | Fucoidan source | Dose (μg/mL) | Effects on cell cycle | Effects on apopotosis pathways | Action characteristic | Action mechanism | Ref |
|---|---|---|---|---|---|---|---|
Huh6 Huh7 SK-Hep1 HepG2 | Sargassum | 200 | – | TGF-β R1, 2↓ Phospho-Smad2/3↓ Smad 4 protein↓ | Colony formation inhibition | Inhibit cell proliferation | [30] |
SMMC-7721 | Undaria pinnatifida | 65.2–1000 | Accumulate in the S-phase | Livin, XIAP mRNA ↓ Caspase-3, -8, -9 ↑ Bax-to-Bcl-2 ratio↑ Cytochrome C ↑ | The quantity of mitochondria ↓ ROS ↑ Depolarization of the MMP | Inhibit cell proliferation Induce cell apoptosis | [54] |
Huh-7 SNU-761 SNU-3085 | Fucus vesiculosus | 1000 | – | Caspase-7, -8, -9 ↑ | – | Inhibit cell proliferation | [55] |
Huh-BAT Huh-7 SNU-761 | Fucus vesiculosus | 100, 250, 500,1000 | sub-G1 fraction↑ | Bax, Bid, Fas↑ Caspase-7, -8, -9 cleavage Phosphorylated-p42/44↑ | – | Inhibit cell proliferation Inhibit metastasis Induce cell apoptosis | [20] |