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Table 4 Effect of fucoidan on hepatoma carcinoma cells in vitro

From: The anti-cancer effects of fucoidan: a review of both in vivo and in vitro investigations

Cell typeFucoidan sourceDose (μg/mL)Effects on cell cycleEffects on apopotosis pathwaysAction characteristicAction mechanismRef
Huh6
Huh7
SK-Hep1
HepG2
Sargassum200TGF-β R1, 2↓
Phospho-Smad2/3↓
Smad 4 protein↓
Colony formation inhibitionInhibit cell proliferation[30]
SMMC-7721Undaria pinnatifida65.2–1000Accumulate in the S-phaseLivin, XIAP mRNA ↓
Caspase-3, -8, -9 ↑
Bax-to-Bcl-2 ratio↑
Cytochrome C ↑
The quantity of mitochondria ↓
ROS ↑
Depolarization of the MMP
Inhibit cell proliferation
Induce cell apoptosis
[54]
Huh-7
SNU-761
SNU-3085
Fucus vesiculosus1000Caspase-7, -8, -9 ↑Inhibit cell proliferation[55]
Huh-BAT
Huh-7
SNU-761
Fucus vesiculosus100, 250,
500,1000
sub-G1 fraction↑Bax, Bid, Fas↑
Caspase-7, -8, -9 cleavage
Phosphorylated-p42/44↑
Inhibit cell proliferation
Inhibit metastasis
Induce cell apoptosis
[20]
  1. IAP inhibitor of apoptotic protein, ROS reactive oxygen species, MMP mitochondrial membrane potential