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Table 4 Effect of fucoidan on hepatoma carcinoma cells in vitro

From: The anti-cancer effects of fucoidan: a review of both in vivo and in vitro investigations

Cell type

Fucoidan source

Dose (μg/mL)

Effects on cell cycle

Effects on apopotosis pathways

Action characteristic

Action mechanism

Ref

Huh6

Huh7

SK-Hep1

HepG2

Sargassum

200

TGF-β R1, 2↓

Phospho-Smad2/3↓

Smad 4 protein↓

Colony formation inhibition

Inhibit cell proliferation

[30]

SMMC-7721

Undaria pinnatifida

65.2–1000

Accumulate in the S-phase

Livin, XIAP mRNA ↓

Caspase-3, -8, -9 ↑

Bax-to-Bcl-2 ratio↑

Cytochrome C ↑

The quantity of mitochondria ↓

ROS ↑

Depolarization of the MMP

Inhibit cell proliferation

Induce cell apoptosis

[54]

Huh-7

SNU-761

SNU-3085

Fucus vesiculosus

1000

Caspase-7, -8, -9 ↑

Inhibit cell proliferation

[55]

Huh-BAT

Huh-7

SNU-761

Fucus vesiculosus

100, 250,

500,1000

sub-G1 fraction↑

Bax, Bid, Fas↑

Caspase-7, -8, -9 cleavage

Phosphorylated-p42/44↑

Inhibit cell proliferation

Inhibit metastasis

Induce cell apoptosis

[20]

  1. IAP inhibitor of apoptotic protein, ROS reactive oxygen species, MMP mitochondrial membrane potential