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Table 5 Effect of fucoidan on leukemia cells in vitro

From: The anti-cancer effects of fucoidan: a review of both in vivo and in vitro investigations

Cell typeFucoidan sourceDose (μg/mL)Effects on cell cycleEffects on apopotosis pathwaysAction characteristicAction mechanismRef
HL-60
NB4
THP-1
Fucus vesiculosus150Sub-G1 fraction ↑PARP cleavage
Caspase-8, 9, 3 ↑
Mcl-1, Bid ↓
ERK1/2,
MEK1/2, JNK ↑
Induce cell apoptosis[56]
SUDHL-4
OCI-LY8
NU-DUL-1
TMD8
U293
DB
Fucus vesiculosus50, 100, 200G0/G1 phase arrest
CyclinD1, CDK4, CDK6↓
p21 ↑
E2F1 ↓
PARP cleavage
Cleaved Caspase-8, 9, 3 ↑
Induce cell apoptosis[58]
NB4
HL60
Fucus vesiculosus12.5, 25, 50, 100Sub-G0/G1 fraction ↑
p21, WAF1, CIP1 ↑
Caspase-3, 8, 9 ↑
PARP cleavage
Bax ↑
Activation of ERK1/2, AKT ↓
NK cell ↑
Inhibit cell proliferation
Induce cell apoptosis
[44]
U937Fucus vesiculosus20–100Sub-G1 fraction ↑Caspase-3, 8, 9 ↑
PARP cleavage
Bax↑
Bid, Bcl-xl, MMP↓
p38MAPK activationInhibit cell proliferation
Induce cell apoptosis
[57]
  1. PARP poly(ADP-ribose) polymerase, ER extracellular signal-regulated kinase, MEK: MAPK kinase, MAPK mitogen-activated protein kinase, JNK Jun NH2-terminal kinase, MMP mitochondrial membrane potential