Table 5 Effect of fucoidan on leukemia cells in vitro
From: The anti-cancer effects of fucoidan: a review of both in vivo and in vitro investigations
Cell type | Fucoidan source | Dose (μg/mL) | Effects on cell cycle | Effects on apopotosis pathways | Action characteristic | Action mechanism | Ref |
|---|---|---|---|---|---|---|---|
HL-60 NB4 THP-1 | Fucus vesiculosus | 150 | Sub-G1 fraction ↑ | PARP cleavage Caspase-8, 9, 3 ↑ Mcl-1, Bid ↓ | ERK1/2, MEK1/2, JNK ↑ | Induce cell apoptosis | [56] |
SUDHL-4 OCI-LY8 NU-DUL-1 TMD8 U293 DB | Fucus vesiculosus | 50, 100, 200 | G0/G1 phase arrest CyclinD1, CDK4, CDK6↓ p21 ↑ E2F1 ↓ | PARP cleavage Cleaved Caspase-8, 9, 3 ↑ | – | Induce cell apoptosis | [58] |
NB4 HL60 | Fucus vesiculosus | 12.5, 25, 50, 100 | Sub-G0/G1 fraction ↑ p21, WAF1, CIP1 ↑ | Caspase-3, 8, 9 ↑ PARP cleavage Bax ↑ | Activation of ERK1/2, AKT ↓ NK cell ↑ | Inhibit cell proliferation Induce cell apoptosis | [44] |
U937 | Fucus vesiculosus | 20–100 | Sub-G1 fraction ↑ | Caspase-3, 8, 9 ↑ PARP cleavage Bax↑ Bid, Bcl-xl, MMP↓ | p38MAPK activation | Inhibit cell proliferation Induce cell apoptosis | [57] |