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Fig. 4 | Cancer Cell International

Fig. 4

From: Hsa_circ_0068307 mediates bladder cancer stem cell-like properties via miR-147/c-Myc axis regulation

Fig. 4

c-Myc overexpression reverses the inhibitory effect of miR-147 on cancer stem cell-mediated BCa cell proliferation and migration in vitro. a, b qRT-PCR assay showing miR-147 (a) and c-Myc (b) expression in T24 and UMUC3 cells. Data are presented as the mean ± SD. ***P < 0.001 vs. NC. ###P < 0.001 vs. si-circRNA. c, d CCK8 assays were performed to assess cell proliferation in T24 (c) and UMUC3 (d) cells. Data are presented as the mean ± SD. *P < 0.05, ***P < 0.001 vs. NC. ###P < 0.001 vs. si-circRNA. e, f Clone formation assay showing the cell proliferation of T24 and UMUC3 cells. Data are presented as the mean ± SD. ***P < 0.001 vs. NC. ##P < 0.01, ###P < 0.001 vs. si-circRNA. g, h Cell migration was determined in T24 and UMUC3 cells using Transwell® assays. Data are presented as the mean ± SD. ***P < 0.001 vs. NC. ###P < 0.001 vs. si-circRNA. i Western blot analysis showing the expression of cancer stem cell-related proteins OCT-4, Sox-2, and NANOG in T24 and UMUC3 cells

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