TY - JOUR AU - Siegel, R. L. AU - Miller, K. D. AU - Jemal, A. PY - 2016 DA - 2016// TI - Cancer statistics, 2016 JO - CA Cancer J Clin VL - 66 UR - https://doi.org/10.3322/caac.21332 DO - 10.3322/caac.21332 ID - Siegel2016 ER - TY - JOUR AU - Travis, W. D. PY - 2011 DA - 2011// TI - Pathology of lung cancer JO - Clin Chest Med VL - 32 UR - https://doi.org/10.1016/j.ccm.2011.08.005 DO - 10.1016/j.ccm.2011.08.005 ID - Travis2011 ER - TY - JOUR AU - Network, C. G. A. R. PY - 2014 DA - 2014// TI - Comprehensive molecular profiling of lung adenocarcinoma JO - Nature VL - 511 UR - https://doi.org/10.1038/nature13385 DO - 10.1038/nature13385 ID - Network2014 ER - TY - JOUR AU - Lin, J. J. AU - Cardarella, S. AU - Lydon, C. A. AU - Dahlberg, S. E. AU - Jackman, D. M. AU - Jänne, P. A. PY - 2016 DA - 2016// TI - Five-year survival in egfr-mutant metastatic lung adenocarcinoma treated with egfr-tkis JO - J Thorac Oncol VL - 11 UR - https://doi.org/10.1016/j.jtho.2015.12.103 DO - 10.1016/j.jtho.2015.12.103 ID - Lin2016 ER - TY - JOUR AU - Detterbeck, F. C. AU - Boffa, D. J. AU - Tanoue, L. T. PY - 2009 DA - 2009// TI - The new lung cancer staging system JO - Chest VL - 136 UR - https://doi.org/10.1378/chest.08-0978 DO - 10.1378/chest.08-0978 ID - Detterbeck2009 ER - TY - JOUR AU - Remark, R. AU - Becker, C. AU - Gomez, J. E. AU - Damotte, D. AU - Dieu-Nosjean, M. -. C. AU - Sautès-Fridman, C. PY - 2015 DA - 2015// TI - The non-small cell lung cancer immune contexture. A major determinant of tumor characteristics and patient outcome JO - Am J Respir Crit Care Med VL - 191 UR - https://doi.org/10.1164/rccm.201409-1671PP DO - 10.1164/rccm.201409-1671PP ID - Remark2015 ER - TY - JOUR AU - Brambilla, E. AU - Teuff, G. AU - Marguet, S. AU - Lantuejoul, S. AU - Dunant, A. AU - Graziano, S. PY - 2016 DA - 2016// TI - Prognostic effect of tumor lymphocytic infiltration in resectable non–small-cell lung cancer JO - J Clin Oncol VL - 34 UR - https://doi.org/10.1200/JCO.2015.63.0970 DO - 10.1200/JCO.2015.63.0970 ID - Brambilla2016 ER - TY - JOUR AU - Kilic, A. AU - Landreneau, R. J. AU - Luketich, J. D. AU - Pennathur, A. AU - Schuchert, M. J. PY - 2011 DA - 2011// TI - Density of tumor-infiltrating lymphocytes correlates with disease recurrence and survival in patients with large non-small-cell lung cancer tumors JO - J Surg Res VL - 167 UR - https://doi.org/10.1016/j.jss.2009.08.029 DO - 10.1016/j.jss.2009.08.029 ID - Kilic2011 ER - TY - JOUR AU - Fridman, W. H. AU - Pages, F. AU - Sautes-Fridman, C. AU - Galon, J. PY - 2012 DA - 2012// TI - The immune contexture in human tumours: impact on clinical outcome JO - Nat Rev Cancer VL - 12 UR - https://doi.org/10.1038/nrc3245 DO - 10.1038/nrc3245 ID - Fridman2012 ER - TY - JOUR AU - Muppa, P. AU - Terra, S. P. B. AU - Sharma, A. AU - Mansfield, A. S. AU - Aubry, M. -. C. AU - Bhinge, K. PY - 2019 DA - 2019// TI - Immune cell infiltration may be a key determinant of long-term survival in small cell lung cancer JO - J Thorac Oncol VL - 14 UR - https://doi.org/10.1016/j.jtho.2019.03.028 DO - 10.1016/j.jtho.2019.03.028 ID - Muppa2019 ER - TY - JOUR AU - Xie, Y. AU - Minna, J. D. PY - 2012 DA - 2012// TI - A lung cancer molecular prognostic test ready for prime time JO - Lancet VL - 379 UR - https://doi.org/10.1016/S0140-6736(12)60154-8 DO - 10.1016/S0140-6736(12)60154-8 ID - Xie2012 ER - TY - JOUR AU - Newman, A. M. AU - Liu, C. L. AU - Green, M. R. AU - Gentles, A. J. AU - Feng, W. AU - Xu, Y. PY - 2015 DA - 2015// TI - Robust enumeration of cell subsets from tissue expression profiles JO - Nat Methods VL - 12 UR - https://doi.org/10.1038/nmeth.3337 DO - 10.1038/nmeth.3337 ID - Newman2015 ER - TY - JOUR AU - Xiong, Y. AU - Wang, K. AU - Zhou, H. AU - Peng, L. AU - You, W. AU - Fu, Z. PY - 2018 DA - 2018// TI - Profiles of immune infiltration in colorectal cancer and their clinical significant: a gene expression-based study JO - Cancer Med VL - 7 UR - https://doi.org/10.1002/cam4.1745 DO - 10.1002/cam4.1745 ID - Xiong2018 ER - TY - JOUR AU - Ali, H. R. AU - Chlon, L. AU - Pharoah, P. D. AU - Markowetz, F. AU - Caldas, C. PY - 2016 DA - 2016// TI - Patterns of immune infiltration in breast cancer and their clinical implications: a gene-expression-based retrospective study JO - PLoS Med VL - 13 UR - https://doi.org/10.1371/journal.pmed.1002194 DO - 10.1371/journal.pmed.1002194 ID - Ali2016 ER - TY - JOUR AU - Rohr-Udilova, N. AU - Klinglmüller, F. AU - Schulte-Hermann, R. AU - Stift, J. AU - Herac, M. AU - Salzmann, M. PY - 2018 DA - 2018// TI - Deviations of the immune cell landscape between healthy liver and hepatocellular carcinoma JO - Sci Rep VL - 8 UR - https://doi.org/10.1038/s41598-018-24437-5 DO - 10.1038/s41598-018-24437-5 ID - Rohr-Udilova2018 ER - TY - JOUR AU - Mony, J. T. AU - Schuchert, M. J. PY - 2018 DA - 2018// TI - Prognostic implications of heterogeneity in intra-tumoral immune composition for recurrence in early stage lung cancer JO - Front Immunol VL - 9 UR - https://doi.org/10.3389/fimmu.2018.02298 DO - 10.3389/fimmu.2018.02298 ID - Mony2018 ER - TY - JOUR AU - Kurbatov, V. AU - Balayev, A. AU - Saffarzadeh, A. AU - Heller, D. R. AU - Boffa, D. J. AU - Blasberg, J. D. PY - 2020 DA - 2020// TI - Digital inference of immune microenvironment reveals low-risk subtype of early lung adenocarcinoma JO - Ann Thorac Surg VL - 109 UR - https://doi.org/10.1016/j.athoracsur.2019.08.050 DO - 10.1016/j.athoracsur.2019.08.050 ID - Kurbatov2020 ER - TY - STD TI - Yamauchi M, Yamaguchi R, Nakata A, Kohno T, Nagasaki M, Shimamura T et al. Epidermal growth factor receptor tyrosine kinase defines critical prognostic genes of stage I lung adenocarcinoma. PloS ONE. 2012;7. ID - ref18 ER - TY - JOUR AU - Rousseaux, S. AU - Debernardi, A. AU - Jacquiau, B. AU - Vitte, A. L. AU - Vesin, A. AU - Nagymignotte, H. PY - 2013 DA - 2013// TI - Ectopic activation of germline and placental genes identifies aggressive metastasis-prone lung cancers JO - Sci Transl Med VL - 5 UR - https://doi.org/10.1126/scitranslmed.3005723 DO - 10.1126/scitranslmed.3005723 ID - Rousseaux2013 ER - TY - JOUR AU - Jabs, V. AU - Edlund, K. AU - König, H. AU - Grinberg, M. AU - Micke, P. PY - 2017 DA - 2017// TI - Integrative analysis of genome-wide gene copy number changes and gene expression in non-small cell lung cancer JO - PLoS ONE VL - 12 UR - https://doi.org/10.1371/journal.pone.0187246 DO - 10.1371/journal.pone.0187246 ID - Jabs2017 ER - TY - JOUR AU - Der, S. D. AU - Sykes, J. AU - Pintilie, M. PY - 2014 DA - 2014// TI - Validation of a histology-independent prognostic gene signature for early-stage, non-small-cell lung cancer including stage ia patients JO - J Throac Ocol. VL - 9 UR - https://doi.org/10.1097/JTO.0000000000000042 DO - 10.1097/JTO.0000000000000042 ID - Der2014 ER - TY - JOUR AU - Shedden, K. AU - Taylor, J. M. G. AU - Enkemann, S. A. AU - Tsao, M. -. S. AU - Yeatman, T. J. AU - Gerald, W. L. PY - 2008 DA - 2008// TI - Gene expression-based survival prediction in lung adenocarcinoma: a multi-site, blinded validation study JO - Nat Med VL - 14 UR - https://doi.org/10.1038/nm.1790 DO - 10.1038/nm.1790 ID - Shedden2008 ER - TY - JOUR AU - Schabath, M. B. AU - Welsh, E. A. AU - Fulp, W. J. AU - Chen, L. AU - Teer, J. K. AU - Thompson, Z. J. PY - 2016 DA - 2016// TI - Differential association of STK11 and TP53 with KRAS mutation-associated gene expression, proliferation and immune surveillance in lung adenocarcinoma JO - Oncogene VL - 35 UR - https://doi.org/10.1038/onc.2015.375 DO - 10.1038/onc.2015.375 ID - Schabath2016 ER - TY - JOUR AU - Leek, J. T. AU - Johnson, W. E. AU - Parker, H. S. AU - Jaffe, A. E. AU - Storey, J. D. PY - 2012 DA - 2012// TI - The sva package for removing batch effects and other unwanted variation in high-throughput experiments JO - Bioinformatics VL - 28 UR - https://doi.org/10.1093/bioinformatics/bts034 DO - 10.1093/bioinformatics/bts034 ID - Leek2012 ER - TY - JOUR AU - Goldstraw, P. AU - Crowley, J. AU - Chansky, K. AU - Giroux, D. J. AU - Groome, P. A. AU - Rami-Porta, R. PY - 2007 DA - 2007// TI - The iaslc lung cancer staging project: proposals for the revision of the TNM stage groupings in the forthcoming (seventh) edition of the TNM classification of malignant tumours JO - J Thorac Oncol VL - 2 UR - https://doi.org/10.1097/JTO.0b013e31812f3c1a DO - 10.1097/JTO.0b013e31812f3c1a ID - Goldstraw2007 ER - TY - JOUR AU - Yoshihara, K. AU - Shahmoradgoli, M. AU - Martínez, E. AU - Vegesna, R. AU - Kim, H. AU - Torres-Garcia, W. PY - 2013 DA - 2013// TI - Inferring tumour purity and stromal and immune cell admixture from expression data JO - Nat Commun VL - 4 UR - https://doi.org/10.1038/ncomms3612 DO - 10.1038/ncomms3612 ID - Yoshihara2013 ER - TY - STD TI - Kassambara A, Kosinski M, Biecek P. Survminer: drawing survival curves using’ggplot2’. R package version 03 2017;1. ID - ref27 ER - TY - JOUR AU - Goeman, J. J. PY - 2010 DA - 2010// TI - L1 penalized estimation in the cox proportional hazards model JO - Biometric J VL - 52 ID - Goeman2010 ER - TY - JOUR AU - Simon, N. AU - Friedman, J. AU - Hastie, T. AU - Tibshirani, R. PY - 2011 DA - 2011// TI - Regularization paths for cox’s proportional hazards model via coordinate descent JO - J Stat Softw VL - 39 UR - https://doi.org/10.18637/jss.v039.i05 DO - 10.18637/jss.v039.i05 ID - Simon2011 ER - TY - JOUR AU - Kamarudin, A. N. AU - Cox, T. AU - Kolamunnage-Dona, R. PY - 2017 DA - 2017// TI - Time-dependent roc curve analysis in medical research: current methods and applications JO - BMC Med Res Methodol VL - 17 UR - https://doi.org/10.1186/s12874-017-0332-6 DO - 10.1186/s12874-017-0332-6 ID - Kamarudin2017 ER - TY - JOUR AU - Uno, H. AU - Claggett, B. AU - Tian, L. AU - Inoue, E. AU - Gallo, P. AU - Miyata, T. PY - 2014 DA - 2014// TI - Moving beyond the hazard ratio in quantifying the between-group difference in survival analysis JO - J Clin Oncol VL - 32 UR - https://doi.org/10.1200/JCO.2014.55.2208 DO - 10.1200/JCO.2014.55.2208 ID - Uno2014 ER - TY - JOUR AU - Subramanian, A. AU - Tamayo, P. AU - Mootha, V. K. AU - Mukherjee, S. AU - Ebert, B. L. AU - Gillette, M. A. PY - 2005 DA - 2005// TI - Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles JO - Proc Natl Acad Sci VL - 102 UR - https://doi.org/10.1073/pnas.0506580102 DO - 10.1073/pnas.0506580102 ID - Subramanian2005 ER - TY - STD TI - Uno H, Tian L, CroninA, Battioui C, Horiguchi M, Uno MH. Package ‘survrm2’. 2017. ID - ref33 ER - TY - JOUR AU - Wakabayashi, O. AU - Yamazaki, K. AU - Oizumi, S. AU - Hommura, F. AU - Kinoshita, I. AU - Ogura, S. PY - 2003 DA - 2003// TI - CD4+ T cells in cancer stroma, not CD8+ T cells in cancer cell nests, are associated with favorable prognosis in human non-small cell lung cancers JO - Cancer Sci VL - 94 UR - https://doi.org/10.1111/j.1349-7006.2003.tb01392.x DO - 10.1111/j.1349-7006.2003.tb01392.x ID - Wakabayashi2003 ER - TY - JOUR AU - Al-Shibli, K. I. AU - Donnem, T. AU - Al-Saad, S. AU - Persson, M. AU - Bremnes, R. M. AU - Busund, L. -. T. PY - 2008 DA - 2008// TI - Prognostic effect of epithelial and stromal lymphocyte infiltration in non-small cell lung cancer JO - Clin Cancer Res VL - 14 UR - https://doi.org/10.1158/1078-0432.CCR-08-0133 DO - 10.1158/1078-0432.CCR-08-0133 ID - Al-Shibli2008 ER - TY - JOUR AU - Kurebayashi, Y. AU - Emoto, K. AU - Hayashi, Y. AU - Kamiyama, I. AU - Ohtsuka, T. AU - Asamura, H. PY - 2016 DA - 2016// TI - Comprehensive immune profiling of lung adenocarcinomas reveals four immunosubtypes with plasma cell subtype a negative indicator JO - Cancer Immunol Res VL - 4 UR - https://doi.org/10.1158/2326-6066.CIR-15-0214 DO - 10.1158/2326-6066.CIR-15-0214 ID - Kurebayashi2016 ER - TY - JOUR AU - Kataki, A. AU - Scheid, P. AU - Piet, M. AU - Marie, B. AU - Martinet, N. AU - Martinet, Y. PY - 2002 DA - 2002// TI - Tumor infiltrating lymphocytes and macrophages have a potential dual role in lung cancer by supporting both host-defense and tumor progression JO - J Lab Clin Med VL - 140 UR - https://doi.org/10.1067/mlc.2002.128317 DO - 10.1067/mlc.2002.128317 ID - Kataki2002 ER - TY - JOUR AU - Tomita, M. AU - Matsuzaki, Y. AU - Onitsuka, T. PY - 1999 DA - 1999// TI - Correlation between mast cells and survival rates in patients with pulmonary adenocarcinoma JO - Lung Cancer VL - 26 UR - https://doi.org/10.1016/S0169-5002(99)00076-8 DO - 10.1016/S0169-5002(99)00076-8 ID - Tomita1999 ER - TY - STD TI - Yang Z, Zhang B, Li D, Lv M, Huang C, Shen GX et al. Mast cells mobilize myeloid-derived suppressor cells and treg cells in tumor microenvironment via il-17 pathway in murine hepatocarcinoma model. Plos ONE. 2010;5. ID - ref39 ER - TY - JOUR AU - Takanami, I. AU - Takeuchi, K. AU - Naruke, M. PY - 2000 DA - 2000// TI - Mast cell density is associated with angiogenesis and poor prognosis in pulmonary adenocarcinoma JO - Cancer VL - 88 UR - https://doi.org/3.0.CO;2-6 DO - 3.0.CO;2-6 ID - Takanami2000 ER - TY - JOUR AU - Ilie, M. AU - Hofman, V. AU - Ortholan, C. AU - Bonnetaud, C. AU - Coëlle, C. AU - Mouroux, J. PY - 2012 DA - 2012// TI - Predictive clinical outcome of the intratumoral CD66b-positive neutrophil-to-CD8-positive t-cell ratio in patients with resectable non-small cell lung cancer JO - Cancer VL - 118 UR - https://doi.org/10.1002/cncr.26456 DO - 10.1002/cncr.26456 ID - Ilie2012 ER - TY - JOUR AU - Rakaee, M. AU - Busund, L. T. AU - Paulsen, E. E. AU - Richardsen, E. AU - Kilvaer, T. K. PY - 2016 DA - 2016// TI - Prognostic effect of intratumoral neutrophils across histological subtypes of non-small cell lung cancer JO - Oncotarget VL - 7 UR - https://doi.org/10.18632/oncotarget.12360 DO - 10.18632/oncotarget.12360 ID - Rakaee2016 ER - TY - JOUR AU - Galon, J. AU - Mlecnik, B. AU - Bindea, G. AU - Angell, H. K. AU - Berger, A. AU - Lagorce, C. PY - 2014 DA - 2014// TI - Towards the introduction of the ‘immunoscore’ in the classification of malignant tumours JO - J Pathol VL - 232 UR - https://doi.org/10.1002/path.4287 DO - 10.1002/path.4287 ID - Galon2014 ER - TY - JOUR AU - Angell, H. AU - Galon, J. PY - 2013 DA - 2013// TI - From the immune contexture to the immunoscore: the role of prognostic and predictive immune markers in cancer JO - Curr Opin Immunol VL - 25 UR - https://doi.org/10.1016/j.coi.2013.03.004 DO - 10.1016/j.coi.2013.03.004 ID - Angell2013 ER - TY - STD TI - Galon J, Pagès F, Marincola FM, Thurin M, Trinchieri G, Fox BA et al. The immune score as a new possible approach for the classification of cancer. BioMed Central. 2012. ID - ref45 ER - TY - JOUR AU - Busch, S. E. AU - Hanke, M. L. AU - Kargl, J. AU - Metz, H. E. AU - MacPherson, D. AU - Houghton, A. M. PY - 2016 DA - 2016// TI - Lung cancer subtypes generate unique immune responses JO - J Immunol VL - 197 UR - https://doi.org/10.4049/jimmunol.1600576 DO - 10.4049/jimmunol.1600576 ID - Busch2016 ER - TY - JOUR AU - Zhou, R. AU - Zhang, J. AU - Zeng, D. AU - Sun, H. AU - Rong, X. AU - Shi, M. PY - 2019 DA - 2019// TI - Immune cell infiltration as a biomarker for the diagnosis and prognosis of stage i–iii colon cancer JO - Cancer Immunol Immunother VL - 68 UR - https://doi.org/10.1007/s00262-018-2289-7 DO - 10.1007/s00262-018-2289-7 ID - Zhou2019 ER - TY - JOUR AU - Zeng, D. AU - Zhou, R. AU - Yu, Y. AU - Luo, Y. AU - Zhang, J. AU - Sun, H. PY - 2018 DA - 2018// TI - Gene expression profiles for a prognostic immunoscore in gastric cancer JO - Br J Surg VL - 105 UR - https://doi.org/10.1002/bjs.10871 DO - 10.1002/bjs.10871 ID - Zeng2018 ER - TY - JOUR AU - Finotello, F. AU - Trajanoski, Z. PY - 2018 DA - 2018// TI - Quantifying tumor-infiltrating immune cells from transcriptomics data JO - Cancer Immunol Immunother VL - 67 UR - https://doi.org/10.1007/s00262-018-2150-z DO - 10.1007/s00262-018-2150-z ID - Finotello2018 ER - TY - JOUR AU - Tibshirani, R. PY - 1997 DA - 1997// TI - The lasso method for variable selection in the cox model JO - Stat Med VL - 16 UR - https://doi.org/3.0.CO;2-3 DO - 3.0.CO;2-3 ID - Tibshirani1997 ER - TY - JOUR AU - Lin, T. AU - Fu, Y. AU - Zhang, X. AU - Gu, J. AU - Ma, X. AU - Miao, R. PY - 2018 DA - 2018// TI - A seven-long noncoding rna signature predicts overall survival for patients with early stage non-small cell lung cancer JO - Aging VL - 10 UR - https://doi.org/10.18632/aging.101550 DO - 10.18632/aging.101550 ID - Lin2018 ER - TY - JOUR AU - Li, B. AU - Cui, Y. AU - Diehn, M. AU - Li, R. PY - 2017 DA - 2017// TI - Development and validation of an individualized immune prognostic signature in early-stage non-squamous non-small cell lung cancer JO - JAMA Oncol VL - 3 UR - https://doi.org/10.1001/jamaoncol.2017.1609 DO - 10.1001/jamaoncol.2017.1609 ID - Li2017 ER - TY - JOUR AU - Song, Q. AU - Shang, J. AU - Yang, Z. AU - Zhang, L. AU - Zhang, C. AU - Chen, J. PY - 2019 DA - 2019// TI - Identification of an immune signature predicting prognosis risk of patients in lung adenocarcinoma JO - J Transl Med. VL - 17 UR - https://doi.org/10.1186/s12967-019-1824-4 DO - 10.1186/s12967-019-1824-4 ID - Song2019 ER - TY - JOUR AU - Holmes, C. E. AU - Ruckdeschel, J. C. AU - Johnston, M. AU - Thomas, P. A. AU - Long, S. PY - 1995 DA - 1995// TI - Randomized trial of lobectomy versus limited resection for t1 n0 non-small-cell lung-cancer JO - Ann Thorac Surg VL - 60 UR - https://doi.org/10.1016/0003-4975(95)00537-U DO - 10.1016/0003-4975(95)00537-U ID - Holmes1995 ER - TY - JOUR AU - Topalian, S. L. AU - Taube, J. M. AU - Anders, R. A. AU - Pardoll, D. M. PY - 2016 DA - 2016// TI - Mechanism-driven biomarkers to guide immune checkpoint blockade in cancer therapy JO - Nat Rev Cancer VL - 16 UR - https://doi.org/10.1038/nrc.2016.36 DO - 10.1038/nrc.2016.36 ID - Topalian2016 ER - TY - JOUR AU - Gibney, G. T. AU - Weiner, L. M. AU - Atkins, M. B. PY - 2016 DA - 2016// TI - Predictive biomarkers for checkpoint inhibitor-based immunotherapy JO - Lancet Oncol VL - 17 UR - https://doi.org/10.1016/S1470-2045(16)30406-5 DO - 10.1016/S1470-2045(16)30406-5 ID - Gibney2016 ER -