Models | Study number (case/control) | Heterogeneity | Association | Bias | |||||
---|---|---|---|---|---|---|---|---|---|
I2 | Pa | Fixed/Random | OR (95% CI) | z | Pb | Pc | Pd | ||
Allelic model (G vs. A) | 69 (19,039/29,707) | 72.0% | < 0.001 | Random | 1.07 (1.01–1.13) | 2.23 | 0.026 | 0.645 | 0.719 |
Carrier model (G vs. A) | 69 (19,039/29,707) | 22.3% | 0.056 | Fixed | 1.04 (1.01–1.08) | 2.62 | 0.009 | 0.637 | 0.727 |
Homozygotic model (GG vs AA) | 69 (19,039/29,707) | 68.9% | < 0.001 | Random | 1.12 (1.00–1.25) | 1.92 | 0.054 | 0.404 | 0.476 |
Heterozygotic model (AG vs. AA) | 69 (19,039/29,707) | 54.2% | < 0.001 | Random | 1.00 (0.92–1.09) | < 0.01 | 0.996 | 0.303 | 0.215 |
Dominant model (AG + GG vs. AA) | 69 (19,039/29,707) | 66.0% | < 0.001 | Random | 1.05 (0.96–1.15) | 1.02 | 0.307 | 0.393 | 0.231 |
Recessive model (GG vs. AA + AG) | 71 (19,257/30,208) | 57.5% | < 0.001 | Random | 1.12 (1.04–1.20) | 3.19 | 0.001 | 0.481 | 0.753 |