Skip to main content

Table 3 Subgroup analyses by race, control source and genotyping assay

From: Association of human XPA rs1800975 polymorphism and cancer susceptibility: an integrative analysis of 71 case–control studies

Models

Factor-subgroup

Study number (case/control)

OR (95% CI)

z

P

Allelic model (G vs. A)

Race-Asian

34 (7941/12,945)

1.03 (0.93–1.13)

0.59

0.558

Race-Caucasian

31 (9809/1,5669)

1.12 (1.06–1.18)

4.01

< 0.001

Control source-PB

53 (15,067/22,560)

1.08 (1.02–1.14)

2.51

0.012

Control source-HB

16 (3888/7302)

1.03 (0.89–1.19)

0.41

0.680

Genotyping assay-PCR-RFLP

40 (7785/11,636)

1.08 (0.98–1.19)

1.59

0.111

Carrier model (G vs. A)

Race-Asian

34 (7941/12,945)

1.00 (0.95–1.05)

0.04

0.964

Race-Caucasian

31 (9809/1,5669)

1.08 (1.03–1.13)

3.46

0.001

Control source-PB

53 (15,067/22,560)

1.05 (1.02–1.09)

2.84

0.005

Control source-HB

16 (3888/7302)

1.01 (0.94–1.08)

0.23

0.815

Genotyping assay-PCR-RFLP

40 (7785/11,636)

1.06 (1.01–1.12)

2.41

0.016

Homozygotic model (GG vs. AA)

Race-Asian

34 (7941/12,945)

1.05 (0.87–1.26)

0.48

0.629

Race-Caucasian

31 (9809/1,5669)

1.24 (1.10–1.39)

3.57

<0.001

Control source-PB

53 (15,067/22,560)

1.15 (1.02–1.29)

2.30

0.022

Control source-HB

16 (3888/7302)

1.04 (0.78–1.39)

0.25

0.805

Genotyping assay-PCR-RFLP

40 (7785/11,636)

1.16 (0.96–1.41)

1.52

0.129

Heterozygotic model (AG vs. AA)

Race-Asian

34 (7941/12,945)

0.97 (0.85–1.09)

0.55

0.584

Race-Caucasian

31 (9809/1,5669)

1.10 (1.00–1.20)

2.00

0.046

Control source-PB

53 (15,067/22,560)

1.04 (0.85–1.14)

0.87

0.385

Control source-HB

16 (3888/7302)

0.87 (0.74–1.03)

1.63

0.103

Genotyping assay-PCR-RFLP

40 (7785/11,636)

1.00 (0.88–1.14)

0.02

0.589

Dominant model (AG + GG vs. AA)

Race-Asian

34 (7941/12,945)

1.00 (0.87–1.14)

0.02

0.988

Race-Caucasian

31 (9809/1,5669)

1.16 (1.05–1.28)

2.86

0.004

Control source-PB

53 (15,067/22,560)

1.09 (0.98–1.20)

1.64

0.101

Control source-HB

16 (3888/7302)

0.94 (0.77–1.15)

0.62

0.535

Genotyping assay-PCR-RFLP

40 (7785/11,636)

1.06 (0.92–1.22)

0.78

0.434

Recessive model (GG vs. AA + AG)

Race-Asian

36 (8243/13,291)

1.08 (0.94–1.22)

1.09

0.276

Race-Caucasian

31 (9809/1,5669)

1.16 (1.08–1.24)

4.18

< 0.001

Control source-PB

55 (15,369/22,906)

1.12 (1.04–1.19)

3.11

0.002

Control source-HB

16 (3888/7302)

1.12 (0.92–1.37)

1.17

0.240

Genotyping assay-PCR-RFLP

40 (7785/11,636)

1.16 (1.03–1.32)

2.37

0.018

  1. OR odds ratio, CI confidence interval, PB population-based control, HB hospital-based control, PCR-RFLP. PCR-restriction fragment length polymorphism