Table 2 The summary of validated circRNA-miRNA-mRNA regulatory axes in lung cancer
From: circRNA-miRNA-mRNA regulatory network in human lung cancer: an update
| Cancer types | Sample | circRNA-miRNA-mRNA | Cell characteristics | Clinical characteristics | Clinical application | References |
|---|---|---|---|---|---|---|
| LAC |
Tissues Plasma Cells |
|
1. Cell proliferation 2. Cell invasion 3. Cell apoptosis 4. Cell migration |
1. TNM stage 2. Lymph node metastasis |
Diagnostic values AUC: 0.815 Sensitivity: 0.755 Specificity: 0.796 | [69, 70] |
| NSCLC | Cells |
| 1. Cell proliferation | – | – | [41] |
| NSCLC |
Tissues Cells |
|
1. Cell proliferation 2. Cell invasion 3. Cell apoptosis 4. Cell migration |
1. T stage 2. Lymph node metastases 3. TNM stage 4. Poor differentiation | – | [71] |
| NSCLC |
Tissues Cells |
|
1. Cell proliferation 2. Cell apoptosis |
1. TNM stage 2. Lymph node metastasis 3. Survival rate | Prognostic value | [72] |
| NSCLC |
Tissues Cells |
|
1. Cell proliferation 2. Cell invasion 3. Cell apoptosis 4. Cell migration |
1. TNM stage 2. Lymph node metastasis 3. Poor differentiation 4. Survival rate | – | [73, 74] |
| LAC |
Tissues Cells |
| 1. Cell proliferation | 1. Tumor size | – | [75] |
| LAC |
Tissues Cells |
|
1. Cell proliferation 2. Cell apoptosis |
1. Poor differentiation 2. TNM stage 3. Lymph node metastasis | – | [76] |
| NSCLC |
Tissues Cells |
|
1. Cell proliferation 2. Cell migration 3. Cell invasion 4. Cell apoptosis |
1. Histological grade 2. N stage 3. TNM stage | – | [77] |
| NSCLC |
Tissues Cells |
|
1. Cell proliferation 2. Cell invasion | – | – | [80] |
| LAC |
Tissues Cells |
|
1. Cell proliferation 2. Cell apoptosis |
1. TNM stage 2. Tumor size 3. T stage 4. Survival rate | Prognostic value | [42] |
| LAC | Tissues |
| – |
1. T stage 2. Distant metastasis |
Diagnostic values AUC: 0.815 | [81] |
| NSCLC |
Tissues Cells |
|
1. Cell proliferation 2. Cell migration 3. Cell invasion 4. Cell apoptosis |
1. TNM stage 2. Lymph node metastasis 3. Survival rate | Prognostic value | [82] |
| NSCLC |
Tissues Cells |
|
1. Cell proliferation 2. Cell migration 3. Cell invasion 4. Cell apoptosis |
1. TNM stage 2. Lymph node metastasis 3. Survival rate | Prognostic value | [83] |
| NSCLC |
Tissues Cells |
|
1. Cell proliferation 2. Cell invasion |
1. Tumor size 2. Lymph node metastasis 3. Survival rate | Prognostic value | [84] |
| NSCLC |
Tissues Cells |
|
1. Cell proliferation 2. Cell migration 3. Cell invasion 4. Cell apoptosis |
1. Poor differentiation 2. Lymph node metastasis 3. T stage and N stage 4. Survival rate | Prognostic value | [85] |
| NSCLC |
Tissues Cell |
|
1. Cell proliferation 2. Cell apoptosis | – | – | [86] |
| NSCLC |
Cells Mice |
|
1. Cell proliferation 2. Cell migration | – | – | [87] |
| LAC |
Tissues Cells Mice |
|
1. Cell proliferation 2. Cell migration 3. Cell invasion 4. Cell apoptosis | 4. TNM stage | – | [88] |
| NSCLC |
Tissues cells |
|
1. Cell proliferation 2. Cell invasion |
1. TNM stage 2. Lymph node metastasis 3. Tumor size 4. Poor differentiation 5. Survival rate | Prognostic value | [89] |
| NSCLC |
Tissues Cells Mice |
|
1. Cell proliferation 2. Cell invasion | 1. Survival rate | Prognostic value | [90] |
| NSCLC |
Tissues Blood Cells |
|
1. Cell proliferation 2. Cell migration 3. Cell invasion 4. Cell apoptosis | 1. Distant metastasis |
Diagnostic values Tissues: AUC: 0.803 Sensitivity: 0.825 Specificity: 0.675 Serum: AUC: 0.794 Sensitivity: 0.711 Specificity: 0.800 | [91] |
| NSCLC |
Tissues Cells |
|
1. Cell proliferation 2. Cell apoptosis |
1. Tumor size 2. TNM stage 3. Survival rate | Prognostic value | [92] |
| LAC |
Tissues Cells |
|
1. Cell proliferation 2. Cell apoptosis |
1. TNM stage 2. Tumor size 3. Survival rate | Prognostic value | [93] |
| NSCLC |
Tissues Cells |
|
1. Cell proliferation 2. Cell invasion 3. Cell apoptosis |
1. TNM stage 2. Lymph node metastasis | – | [94] |
| NSCLC |
Tissues Cells |
|
1. Cell proliferation 2. Cell invasion 3. Cell apoptosis | – |
Diagnostic values AUC: 0.643 Sensitivity: 0.725 Specificity: 0.575 | [95] |
| NSCLC |
Tissues Cells |
|
1. Cell proliferation 2. Cell migration 3. Cell invasion |
1. TNM stage 2. Distant metastasis 3. Poor differentiation | – | [96] |
| NSCLC |
Tissues Cells |
|
1. Cell proliferation 2. Cell migration 3. Cell invasion 4. Cell apoptosis |
1. Lymph node metastasis 2. Poor differentiation 3. Survival rate | – | [97] |
| NSCLC |
Tissues Cells |
|
1. Cell proliferation 2. Cell migration 3. Cell invasion 4. Cell apoptosis |
1. TNM stage 2. Lymph node metastasis 3. Survival rate | Prognostic value | [98] |
| NSCLC |
Tissues Cells |
|
1. Cell proliferation 2. Cell invasion 3. Cell apoptosis |
1. TNM stage 2. T stage 3. Poor differentiation 4. Survival rate | Prognostic value | [99] |
| NSCLC |
Tissues Cells |
|
1. Cell migration 2. Cell invasion |
1. Lymph node metastasis 2. Prognostic value | Prognostic value | [100] |
| NSCLC |
TISSUES Cells |
|
1. Cell proliferation 2. Cell migration 3. Cell invasion 4. Cell apoptosis | – | – | [101] |
| NSCLC |
Tissues Cells |
|
1. Cell proliferation 2. Cell migration 3. Cell invasion 4. Cell apoptosis |
1. TNM stage 2. Lymph node metastasis | Prognostic value | [102] |
| SCLC |
Tissues Blood |
|
1. Cell proliferation 2. Cell migration 3. Cell apoptosis |
1. Lymph node metastasis 2. Survival rate | Prognostic value | [103] |
| NSCLC |
Tissues Cells |
| 1. Cell proliferation |
1. Patients’ age (particularly after the age of 60) 2. TNM stage | – | [104] |
| NSCLC |
Tissues Cells |
|
1. Cell proliferation 2. Cell invasion 3. Cell apoptosis |
1. TNM stage 2. Lymph node metastasis 3. Survival rate | Prognostic value | [105] |
| NSCLC |
Tissues Cells |
|
1. Cell invasion 2. Cell metastasis | – | – | [106] |
| NSCLC |
Tissues Cells |
|
1. Cell proliferation 2. Cell migration 3. Cell invasion |
1. TNM stage 2. Lymph node metastasis 3. Survival rate | Prognostic value | [107] |
| NSCLC |
Tissues Cells |
|
1. Cell proliferation 2. Cell migration 3. Cell invasion |
1. TNM stage 2. Lymph node metastasis 3. Survival rate | Prognostic value | [108] |
| NSCLC |
Tissues Cells |
|
1. Cell proliferation 3. Cell apoptosis | – | – | [109] |
| NSCLC |
Tissues Cells |
|
1. Cell proliferation 2. Cell migration 3. Cell invasion | – |
Diagnostic values AUC: 0.782 Sensitivity: 0.800 Specificity: 0.733 | [110] |
| LAC |
Tissues Cells |
|
1. Cell migration 2. Cell invasion |
1. TNM stage 2. Lymph node metastasis | – | [111] |
| LAC |
Tissues Cells |
|
1. Cell proliferation 2. Cell migration 3. Cell invasion |
1. TNM stage 2. Lymph node metastasis 3. Tumor size 4. Survival rate | Prognostic value | [112] |
| LAC |
Tissues Cells |
|
1. Cell proliferation 2. Cell migration 3. Cell invasion |
1. T stage 2. Cell proliferation 3. Cell migration and invasion | – | [113] |