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Table 2 The summary of validated circRNA-miRNA-mRNA regulatory axes in lung cancer

From: circRNA-miRNA-mRNA regulatory network in human lung cancer: an update

Cancer types Sample circRNA-miRNA-mRNA Cell characteristics Clinical characteristics Clinical application References
LAC Tissues
Plasma
Cells
1. Cell proliferation
2. Cell invasion
3. Cell apoptosis
4. Cell migration
1. TNM stage
2. Lymph node metastasis
Diagnostic values
AUC: 0.815
Sensitivity: 0.755
Specificity: 0.796
[69, 70]
NSCLC Cells 1. Cell proliferation [41]
NSCLC Tissues
Cells
1. Cell proliferation
2. Cell invasion
3. Cell apoptosis
4. Cell migration
1. T stage
2. Lymph node metastases
3. TNM stage
4. Poor differentiation
[71]
NSCLC Tissues
Cells
1. Cell proliferation
2. Cell apoptosis
1. TNM stage
2. Lymph node metastasis
3. Survival rate
Prognostic value [72]
NSCLC Tissues
Cells
1. Cell proliferation
2. Cell invasion
3. Cell apoptosis
4. Cell migration
1. TNM stage
2. Lymph node metastasis
3. Poor differentiation
4. Survival rate
[73, 74]
LAC Tissues
Cells
1. Cell proliferation 1. Tumor size [75]
LAC Tissues
Cells
1. Cell proliferation
2. Cell apoptosis
1. Poor differentiation
2. TNM stage
3. Lymph node metastasis
[76]
NSCLC Tissues
Cells
1. Cell proliferation
2. Cell migration
3. Cell invasion
4. Cell apoptosis
1. Histological grade
2. N stage
3. TNM stage
[77]
NSCLC Tissues
Cells
1. Cell proliferation
2. Cell invasion
[80]
LAC Tissues
Cells
1. Cell proliferation
2. Cell apoptosis
1. TNM stage
2. Tumor size
3. T stage
4. Survival rate
Prognostic value [42]
LAC Tissues 1. T stage
2. Distant metastasis
Diagnostic values
AUC: 0.815
[81]
NSCLC Tissues
Cells
1. Cell proliferation
2. Cell migration
3. Cell invasion
4. Cell apoptosis
1. TNM stage
2. Lymph node metastasis
3. Survival rate
Prognostic value [82]
NSCLC Tissues
Cells
1. Cell proliferation
2. Cell migration
3. Cell invasion
4. Cell apoptosis
1. TNM stage
2. Lymph node metastasis
3. Survival rate
Prognostic value [83]
NSCLC Tissues
Cells
1. Cell proliferation
2. Cell invasion
1. Tumor size
2. Lymph node metastasis
3. Survival rate
Prognostic value [84]
NSCLC Tissues
Cells
1. Cell proliferation
2. Cell migration
3. Cell invasion
4. Cell apoptosis
1. Poor differentiation
2. Lymph node metastasis
3. T stage and N stage
4. Survival rate
Prognostic value [85]
NSCLC Tissues
Cell
1. Cell proliferation
2. Cell apoptosis
[86]
NSCLC Cells
Mice
1. Cell proliferation
2. Cell migration
[87]
LAC Tissues
Cells
Mice
1. Cell proliferation
2. Cell migration
3. Cell invasion
4. Cell apoptosis
4. TNM stage [88]
NSCLC Tissues
cells
1. Cell proliferation
2. Cell invasion
1. TNM stage
2. Lymph node metastasis
3. Tumor size
4. Poor differentiation
5. Survival rate
Prognostic value [89]
NSCLC Tissues
Cells
Mice
1. Cell proliferation
2. Cell invasion
1. Survival rate Prognostic value [90]
NSCLC Tissues
Blood
Cells
1. Cell proliferation
2. Cell migration
3. Cell invasion
4. Cell apoptosis
1. Distant metastasis Diagnostic values
Tissues:
AUC: 0.803
Sensitivity: 0.825
Specificity: 0.675
Serum:
AUC: 0.794
Sensitivity: 0.711
Specificity: 0.800
[91]
NSCLC Tissues
Cells
1. Cell proliferation
2. Cell apoptosis
1. Tumor size
2. TNM stage
3. Survival rate
Prognostic value [92]
LAC Tissues
Cells
1. Cell proliferation
2. Cell apoptosis
1. TNM stage
2. Tumor size
3. Survival rate
Prognostic value [93]
NSCLC Tissues
Cells
1. Cell proliferation
2. Cell invasion
3. Cell apoptosis
1. TNM stage
2. Lymph node metastasis
[94]
NSCLC Tissues
Cells
1. Cell proliferation
2. Cell invasion
3. Cell apoptosis
Diagnostic values
AUC: 0.643
Sensitivity: 0.725
Specificity: 0.575
[95]
NSCLC Tissues
Cells
1. Cell proliferation
2. Cell migration
3. Cell invasion
1. TNM stage
2. Distant metastasis
3. Poor differentiation
[96]
NSCLC Tissues
Cells
1. Cell proliferation
2. Cell migration
3. Cell invasion
4. Cell apoptosis
1. Lymph node metastasis
2. Poor differentiation
3. Survival rate
[97]
NSCLC Tissues
Cells
1. Cell proliferation
2. Cell migration
3. Cell invasion
4. Cell apoptosis
1. TNM stage
2. Lymph node metastasis
3. Survival rate
Prognostic value [98]
NSCLC Tissues
Cells
1. Cell proliferation
2. Cell invasion
3. Cell apoptosis
1. TNM stage
2. T stage
3. Poor differentiation
4. Survival rate
Prognostic value [99]
NSCLC Tissues
Cells
1. Cell migration
2. Cell invasion
1. Lymph node metastasis
2. Prognostic value
Prognostic value [100]
NSCLC TISSUES
Cells
1. Cell proliferation
2. Cell migration
3. Cell invasion
4. Cell apoptosis
[101]
NSCLC Tissues
Cells
1. Cell proliferation
2. Cell migration
3. Cell invasion
4. Cell apoptosis
1. TNM stage
2. Lymph node metastasis
Prognostic value [102]
SCLC Tissues
Blood
1. Cell proliferation
2. Cell migration
3. Cell apoptosis
1. Lymph node metastasis
2. Survival rate
Prognostic value [103]
NSCLC Tissues
Cells
1. Cell proliferation 1. Patients’ age (particularly after the age of 60)
2. TNM stage
[104]
NSCLC Tissues
Cells
1. Cell proliferation
2. Cell invasion
3. Cell apoptosis
1. TNM stage
2. Lymph node metastasis
3. Survival rate
Prognostic value [105]
NSCLC Tissues
Cells
1. Cell invasion
2. Cell metastasis
[106]
NSCLC Tissues
Cells
1. Cell proliferation
2. Cell migration
3. Cell invasion
1. TNM stage
2. Lymph node metastasis
3. Survival rate
Prognostic value [107]
NSCLC Tissues
Cells
1. Cell proliferation
2. Cell migration
3. Cell invasion
1. TNM stage
2. Lymph node metastasis
3. Survival rate
Prognostic value [108]
NSCLC Tissues
Cells
1. Cell proliferation
3. Cell apoptosis
[109]
NSCLC Tissues
Cells
1. Cell proliferation
2. Cell migration
3. Cell invasion
Diagnostic values
AUC: 0.782
Sensitivity: 0.800
Specificity: 0.733
[110]
LAC Tissues
Cells
1. Cell migration
2. Cell invasion
1. TNM stage
2. Lymph node metastasis
[111]
LAC Tissues
Cells
1. Cell proliferation
2. Cell migration
3. Cell invasion
1. TNM stage
2. Lymph node metastasis
3. Tumor size
4. Survival rate
Prognostic value [112]
LAC Tissues
Cells
1. Cell proliferation
2. Cell migration
3. Cell invasion
1. T stage
2. Cell proliferation
3. Cell migration and invasion
[113]