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Fig. 4 | Cancer Cell International

Fig. 4

From: CRNDE: an oncogenic long non-coding RNA in cancers

Fig. 4

CRNDE influences drug resistance, radiation resistance and immune response, participants in glucose metabolism and also acts as a gene scaffold. CRNDE triggers inflammation to regulate tumorigenesis by targeting FOXM1 and TLR3/MyD8 axis, and activating NF-κB and JAK/STAT signaling pathways. Moreover, CRNDE leads to the formation of drug-resistance and radiation-tolerant phenotypes through interacting with EZH2, miR-181a-5p and miR-136. Furthermore, CRNDE can be regulated by insulin and IGFs through the PI3K/Akt/mTOR and the Raf/MAPK pathways to take part in aerobic glycolysis (Warburg effect). Especially, CRNDE functions as the scaffold of DMBT1 and C-IAP1 to help them exert their effect in cancers. All these illustrates that CRNDE play different important roles in the complicated networks of cancers

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