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Table 1 The related interactive genes of CRNDE and involvement in functional role in different cancers

From: CRNDE: an oncogenic long non-coding RNA in cancers

Functional roles Cancer types Related genes Related pathways References
Proliferation CRC miR-217/TCF7L2, hnRNPUL2, miR-181a-5p/beta-catenin/TCF4, EZH2/DUSP5/CDKN1A Wnt/beta-catenin, Ras/MAPK signaling pathway [32, 33, 35, 48]
Glioma miR-384/PIWIL4, miR-136-5p/Bcl-2/Wnt2,
miR-186/XIAP/PAK7
mTOR signaling pathway [19, 39,40,41]
Lung caner miR-338-3p, CDK4, CDK6, CCNE1 PI3K/AKT signaling pathway [25, 26]
HCC miR-136-5P/IRX5,miR-217/MAPK1, miR-203/BCAT1, miR-384/NF-kappaB/p-AKT, E-cadherin, ZO-1, N-cadherin, slug, twist, vimentin PI3K/Akt/GSK3beta-Wnt/beta-catenin, mTOR signaling pathway [20,21,22,23,24, 38, 77]
BC miR-136, SF3B1 Wnt/beta-catenin signaling pathway [27, 78]
GC miR-145/E2F3 PI3K/AKT signaling pathway [28, 29]
RCC CCND1, CCNE1 Wnt/beta-catenin signaling pathway [31, 79]
Osteosarcoma Notch1, JAG1, N-cadherin, vimentin, E-cadherin Notch1 signaling pathway [36]
Cervical cancer Not determined PI3K/AKT signaling pathway [34, 80]
Ovarian cancer TP53 Not determined [66]
MM miR-451 Not determined [47]
PTC miR-384/PTN Not determined [43]
Pancreatic cancer miR-384/IRS1 Not determined [50]
TSCC miR-384/KRAS/cdc42 Not determined [42]
Melanoma miR-205/CCL18, SF3B1 Not determined [81, 82]
Medulloblastoma Not determined Not determined [83]
Bladder cancer Not determined Not determined [68]
Invasion and migration CRC miR-136/E2F1, miR-217/TCF7L2, hnRNPUL2 Wnt/beta-catenin, Ras/MAPK Signaling Pathway [32, 35, 49]
Glioma miR-384/PIWIL4/STAT3, miR-136-5p/Bcl-2/Wnt2, miR-186/XIAP/PAK7 mTOR signaling pathway [19, 39,40,41]
Lung caner miR-338-3p Not determined [25]
HCC miR-136-5P/IRX5, miR-217/MAPK1, miR-203/BCAT1, miR-384/NF-kappaB/p-AKT,E-cadherin, ZO-1, N-cadherin, slug, twist, vimentin Wnt/beta-catenin signaling pathway [20,21,22, 24, 38]
BC miR-136 Wnt/beta-catenin signaling pathway [27]
GC Not determined PI3K/AKT signaling pathway [28]
Osteosarcoma Notch1, JAG1, N-cadherin, vimentin, E-cadherin Notch1 signaling pathway [36]
Cervical cancer Not determined PI3K/AKT signaling pathway [80]
PTC miR-384/PTN Not determined [43]
Pancreatic cancer miR-384/IRS1 Not determined [50]
TSCC miR-384/KRAS/cdc42 Not determined [42]
Melanoma miR-205/CCL18 Not determined [81]
Gallbladder cancer DMBT1/C-IAP1 PI3K-AKT signaling pathway [76]
Bladder cancer Not determined Not determined [68]
Apoptosis CRC EZH2/DUSP5/CDKN1A Not determined [48]
Glioma miR-384/PIWIL4/STAT3, EGFR/TKI, Bcl2/Bax, miR-136-5p/Bcl-2/Wnt2, miR-186/XIAP/PAK7, FOXM1 EGFR, NF-kappaB, JAK/STAT signaling pathway [39,40,41, 46, 58]
HCC Not determined mTOR signaling pathway [77]
Cervical cancer Not determined PI3K/AKT signaling pathway [34]
MM miR-451 Not determined [47]
Medulloblastoma Not determined Not determined [83]
Bladder cancer Not determined Not determined [68]
Chemoresistance CRC miR-181a-5p/beta-catenin/TCF4, miR-136/E2F1 Wnt/beta-catenin signaling pathway [33, 49]
Metabolism CRC IGF PI3K/Akt/mTOR, Raf/MAPK, insulin/IGF signaling pathway [74]
Radiosensitivity Lung caner PRC2/EZH2/p21 Not determined [64]
Inflammation Glioma FOXM1 NF-kappaB, JAK/STAT, toll-like receptor (TLR) signaling pathway [58, 59]