Fig. 9From: HE4 overexpression decreases pancreatic cancer Capan-1 cell sensitivity to paclitaxel via cell cycle regulationHE4 overexpression in PDAC tissues. Immunohistochemistry was performed on a PDAC microarray using the HE4-specific antibodies. a, b Two normal pancreatic tissues without negative HE4 staining. c, d High HE4 expression was detected in the two PDAC tissues. High HE4 expression was found in the glandular cancer cells, whereas low or no HE4 expression was found in the stromal compartment. HE4 protein mostly localized in the cytoplasm rather than nuclei. Representative images were taken at 20× magnification. Cell nuclei were highlighted in purple color by Hematoxylin staining. After color development with DAB, HE4 staining was shown in brown colorBack to article page