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Fig. 9 | Cancer Cell International

Fig. 9

From: Biological effects of selective COX-2 inhibitor NS398 on human glioblastoma cell lines

Fig. 9

NS398 inhibited wound healing ability of GBM cell lines. Representative phase-contrast micrographs and quantification of scratch assays performed in a U87MG and b T98G GBM cell lines treated with NS398 or with drug vehicle DMSO (CNTR), immediately after the scratch at the initial time (T0) and after 8 h and 24 h. Representative phase-contrast micrographs and quantification of scratch assays performed in (c) U87MG and d T98G GBM cell lines after incubation with EV derived from control (CNTR) neurospheres (+EV CNTR-NS) or NS398-treated neurospheres (+EV NS398-NS). Original magnification 10x. The results, expressed as  % wound closure vs relative T0 (mean ± SD), are representative of two independent experiments in duplicate. For comparative analysis of groups of data, two-way ANOVA followed by Bonferroni post hoc test was used (*p < 0.05, **p < 0.01, ****p < 0.0001)

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