Fig. 6From: N-alkylisatin-based microtubule destabilizers bind to the colchicine site on tubulin and retain efficacy in drug resistant acute lymphoblastic leukemia cell lines with less in vitro neurotoxicityVinca alkaloids significantly alter the neurite morphology of retinoic acid differentiated SH-SY5Y cells. Automated segmentation of neurites (orange) and calcein AM stained cell body clusters (green) of retinoic acid-differentiated SH-SY5Y cells after overnight incubation with a 1% DMSO vehicle control, or 10 nM b vincristine, c vinblastine or d HMB-isatin. Images we obtained using Neurotrack and the IncuCyte® live-cell analysis systemBack to article page