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Fig. 6 | Cancer Cell International

Fig. 6

From: N-alkylisatin-based microtubule destabilizers bind to the colchicine site on tubulin and retain efficacy in drug resistant acute lymphoblastic leukemia cell lines with less in vitro neurotoxicity

Fig. 6

Vinca alkaloids significantly alter the neurite morphology of retinoic acid differentiated SH-SY5Y cells. Automated segmentation of neurites (orange) and calcein AM stained cell body clusters (green) of retinoic acid-differentiated SH-SY5Y cells after overnight incubation with a 1% DMSO vehicle control, or 10 nM b vincristine, c vinblastine or d HMB-isatin. Images we obtained using Neurotrack and the IncuCyte® live-cell analysis system

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Cancer Cell International

ISSN: 1475-2867

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