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Table 2 Binding affinity values for HMB-isatin, I4M-isatin and N1M-isatin compared with reference compounds of the colchicine site

From: N-alkylisatin-based microtubule destabilizers bind to the colchicine site on tubulin and retain efficacy in drug resistant acute lymphoblastic leukemia cell lines with less in vitro neurotoxicity

Compound

Binding affinity (M−1) ± SEMa

Colchicine

1.16 × 107 (37 °C) [70]

Podophyllotoxin

1.8 × 106 [71]

MTC

4.7 × 105 [72]

HMB-isatin

2.7 ± 1.1 × 105

I4M-isatin

3.4 ± 1.5 × 105

N1M-isatin

1.4 ± 0.2 × 105(× 104)

  1. aValues (Kb) are the mean of three independent experiments performed in triplicate (n = 9) ± SEM
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Cancer Cell International

ISSN: 1475-2867

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