Skip to main content

Table 2 Sensitivity analysis and publication bias

From: Clinicopathological and prognostic significance of nestin expression in patients with breast cancer: a systematic review and meta-analysis

 

Sensitivity analysis

Publication bias (P value)

HR/OR fluctuation

95% CI fluctuation

Begg’s test

Egger’s test

Nestin expression and survival outcomes

 BCSS(U)

2.061–2.488

1.741–3.357

0.060

0.065

 BCSS(M)

1.240–2.000

1.000–3.810

1.000

–

 OS(U)

1.648–2.117

1.202–3.386

0.260

0.018

 OS(M)

1.715–2.362

0.862–6.474

1.000

0.536

 DMFS(U)

1.040–1.993

0.674–3.564

1.000

–

 RFS(U)

2.575–2.640

1.150–6.061

1.000

–

Nestin expression and clinicopathological parameters

 Age (> 35 vs. < 35)

0.375–0.809

0.200–2.529

1.000

0.437

 TNM stage (III vs. I-II)

4.051–5.924

2.337–10.828

0.876

0.386

 T stage (T2–4 vs. T1)

1.256–1.568

1.046–2.097

0.917

0.340

 N stage (N+ vs. N0)

0.893–1.114

0.637–1.586

0.755

0.358

 IDC vs. DCIS

1.280–1.477

0.428–3.928

1.000

0.817

 IDC vs. ILC

1.927–3.935

0.890–10.835

0.221

0.056

 LVI (positive vs. negative)

0.806–1.021

0.656–1.505

1.000

0.484

 BVI (positive vs. negative)

2.558–2.683

0.936–7.689

1.000

–

 VPI (high vs. low)

2.958–3.043

1.650–5.302

0.296

0.066

Nestin expression and immunohistochemical markers

 ER (positive vs. negative)

0.107–0.134

0.064–0.208

0.243

0.306

 PR (positive vs. negative)

0.167–0.218

0.105–0.341

0.474

0.455

 HER2 (positive vs. negative)

0.610–0.826

0.321–1.268

0.013

0.068

 Ki-67 (high vs. low)

4.998–7.542

2.807–14.262

0.462

0.059

 TNBC vs. Non-TNBC

7.898–10.775

5.246–18.386

0.348

0.657

 CK5 (positive vs. negative)

7.605–9.786

5.983–14.333

0.462

0.023

 P-cadherin (positive vs. negative)

7.440–8.244

4.945–12.964

0.308

0.123

 EGFR (positive vs. negative)

6.306–7.034

3.962–10.244

1.000

0.888

 BLP1 (present vs. absent)

19.543–23.784

11.296–41.447

1.000

0.629

 BLP2 (present vs. absent)

15.339–20.293

9.432–33.109

0.308

0.280

 BLP3 (present vs. absent)

12.265–13.134

4.821–31.205

0.296

0.253

 BLP4 (present vs. absent)

19.715–23.878

9.672–48.403

0.296

0.468

 BLP5 (present vs. absent)

22.230–26.590

11.294–53.144

1.000

0.683

 p53 (positive vs. negative)

3.906–5.397

2.619–8.421

0.221

0.055

 FOXA1 (positive vs. negative)

0.043–0.241

0.009–0.593

1.000

–