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Fig. 4 | Cancer Cell International

Fig. 4

From: Circular RNA circ-MAT2B facilitates glycolysis and growth of gastric cancer through regulating the miR-515-5p/HIF-1α axis

Fig. 4

Circ-MAT2B sponges miR-515-5p and upregulates HIF-1α. a The indicated three online tools predicting seven genes bound by miR-515-5p. b qRT-PCR analysis of seven gene levels in miR-515-5p-overexpressing AGS and MKN45 cells. c The luciferase reporter assay in AGS and MKN45 cells co-transfected with miR-515-5p mimics and the indicated luciferase HIF-1α-3`-UTR vector. d, e The expression level of HIF-1α in circ-MAT2B-depleted GC cells transfected with miR-515-5p inhibitors. f qRT-PCR analysis of HIF-1α in GC and normal tissues. g, h The indicated functional assays in circ-MAT2B knockdown GC cells transfected with HIF-1α-overexpreesing plasmid. **p < 0.01, ***p < 0.001

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