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Fig. 4 | Cancer Cell International

Fig. 4

From: LncRNA MEG3 suppressed the progression of ovarian cancer via sponging miR-30e-3p and regulating LAMA4 expression

Fig. 4

LAMA4 negatively regulated the proliferation, migration, invasion of ovarian cancer cells, and tumorigenesis in animal models. a The proliferation of SKOV3 and OVCAR3 cells with LAMA4 over-expression was detected by CCK8 assay. OD450 optical density at 450 nm. b The proliferation of SKOV3 and OVCAR3 cells with LAMA4 over-expression was further determined using colony foci formation assay. c The ability of cell migration in SKOV3 and OVCAR3 cells with LAMA4 over-expression was evaluated by wound healing assay. The migration rate was calculated as (wound width at 0 h − wound width at 48 h)/wound width at 0 h ×100%. d The ability of cell invasion was assessed in SKOV3 and OVCAR3 cells with LAMA4 over-expression using transwell invasion assay. e The bioluminescence results showing the tumorigenesis in vivo. Control group is the blank group. NC, the cells were transfected with empty plasmids. LAMA4 OE, the cells were transfected with LAMA4 over-expression plasmids. *P < 0.05 and **P < 0.01 vs. control

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