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Fig. 6 | Cancer Cell International

Fig. 6

From: LncRNA H19 promotes triple-negative breast cancer cells invasion and metastasis through the p53/TNFAIP8 pathway

Fig. 6

LncRNA H19 promotes xenograft growth via regulating p53/TNFAIP8 axis in vivo. a Tumor volume of the xenografts was remarkably inhibited by depletion of lncRNA H19 or TNFAIP 8. b The xenograft tumors were significantly depressed (left) and tumor weight was remarkably reduced by lncRNA H19 or TNFAIP8 depletion. c Silencing of lncRNA H19 or TNFAIP8 significantly reduced the expression levels of lncRNA H19 in vivo detected by qRT-PCR. d The protein levels of TNFAIP8, p53, and EMT markers in the xenografted tissues detected by Western blotting analyses. e The lymph node metastases were significantly inhibited by lncRNA H19 or TNFAIP8 depletion. f Tumor lymph angiogenesis was significantly reduced by lncRNA H19 or TNFAIP8 depletion. g Histopathological analysis (HE staining and TNFAIP8 IHC staining) of the lymph node samples isolated from xenografted mice. Original magnification, 100× . Measurements were carried out in triplicate, and experiments were repeated three times. Data are presented as mean ± SD. *p < 0.05 and **p < 0.01

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