Fig. 2

CHAF1B regulates NCOR2 expression and low NCOR2 expression leads to cisplatin resistance. a After CHAF1B was knocked down, NCOR2 expression increased while PPP5C did not change significantly; b, c MTT and flow cytometry showed that the sensitivity of lung adenocarcinoma cells to cisplatin decreased, cell proliferation increased and apoptosis decreased after NCOR2 was knocked down in A549 cells. **p < 0.01, ***p < 0.001. DDP: IC25 concentration of cisplatin to A549/DDP