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Fig. 6 | Cancer Cell International

Fig. 6

From: FOXC2 is a prognostic biomarker and contributes to the growth and invasion of human hepatocellular carcinoma

Fig. 6

FOXC2 facilitates in vivo and in vitro proliferation of HCC through Ang-2. a Representative images of NOD/SCID mice injected with FOXC2 OE and FOXC2 OE Ang-2 KD Huh-7 cells at day7, 9, 11 and 13. b Quantification analysis of bioluminescent signal of tumor-bearing mice injected with FOXC2 OE or FOXC2 OE Ang-2 KD Huh-7 cells at specified time points. Ang-2 downregulation impeded proliferation of FOXC2 OE Huh-7 cells c Tumor volume of FOXC2 OE Huh-7 cells were decreased with Ang-2 downregulation. d Tumor weight of FOXC2 OE Huh-7 cells were lightened with Ang-2 knockdown. e Ang-2 and FOXC2 expression in FOXC2 OE and FOXC2 OE Ang-2 KD tumors were analyzed through western blot. Values are presented as mean ± SEM. Significance at p < 0.01 is denoted by ‘*’ relative to control by one-way ANOVA

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Cancer Cell International

ISSN: 1475-2867

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