|
Characteristics
|
FAHSU cohort (N = 46)
|
GEO cohort (N = 93)
|
TCGA cohort (N = 472)
|
|---|
|
N (%)
|
|
Age
|
|
≤ 60 years
|
21 (45.6)
|
53 (56.9)
|
258 (54.7)
|
|
> 60 years
|
25 (54.4)
|
40 (43.1)
|
214 (45.3)
|
|
Gender
|
|
Male
|
30 (65.2)
|
55 (59.1)
|
297 (61.9)
|
|
Female
|
16 (34.8)
|
38 (40.9)
|
183 (38.1)
|
|
Clark level
|
|
I
|
6 (13.0)
|
13 (13.9)
|
6 (1.8)
|
|
II
|
25 (54.3)
|
25 (26.8)
|
18 (5.5)
|
|
III–IV
|
12 (26.1)
|
47 (50.7)
|
246(75.5)
|
|
V
|
3 (6.6)
|
8 (8.6)
|
56 (17.2)
|
|
Breslow depth(mm)
|
|
≤ 0.75
|
5 (10.9)
|
15 (16.1)
|
36 (10.2)
|
|
0.76–1.50
|
28 (60.9)
|
30 (32.2)
|
65 (18.4)
|
|
1.51–4.00
|
11 (23.9)
|
39 (41.9)
|
106 (30.0)
|
|
> 4.00
|
2 (4.3)
|
9 (9.8)
|
146 (41.4)
|
|
pT stage
|
|
T1–T2
|
32 (69.6)
|
57 (61.3)
|
121 (32.7)
|
|
T3–T4
|
14 (30.4)
|
36 (38.7)
|
249 (67.3)
|
|
pN stage
|
|
N0
|
46 (100)
|
93 (100)
|
236 (65.0)
|
|
N1
|
0 (0)
|
0 (0)
|
75 (20.7)
|
|
N2
|
0 (0)
|
0 (0)
|
52 (14.3)
|
|
pM stage
|
|
M0
|
46 (100)
|
93 (100)
|
424 (94.4)
|
|
M1
|
0 (0)
|
0 (0)
|
25 (5.6)
|
|
Pathologic stage
|
|
I–II
|
46 (100)
|
93 (100)
|
233 (53.9)
|
|
III–IV
|
0 (0)
|
0 (0)
|
199 (46.1)
|
|
Persistent distant metastasis
|
|
No
|
46 (100)
|
93 (100)
|
217 (46.1)
|
|
Yes
|
0 (0)
|
0 (0)
|
254 (53.9)
|
- SKCM, Skin Cutaneous Melanoma
- FAHSU, The First Affiliated Hospital of Soochow University
- GEO, The Gene Expression Omnibus
- TCGA, The Cancer Genome Atlas
