Table 2 Key transcriptional factors (TFs) of five chemokines in SKCM (TRRUST database)
Key TF | Description | P-value | FDR | Regulated genes |
|---|---|---|---|---|
IRF7 | Interferon regulatory factor 7 | 7.77E−06 | 3.09E−05 | CCL5, CXCL10 |
IRF3 | Interferon regulatory factor 3 | 1.24E−05 | 3.09E−05 | CXCL10, CCL5 |
RELA | v-Rel reticuloendotheliosis viral oncogene homolog A (avian) | 0.000134 | 0.000149 | CCL4, CXCL10, CCL5 |
NFKB1 | Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.000137 | 0.000149 | CCL5, CXCL10, CCL4 |
IRF1 | Interferon regulatory factor 1 | 0.000149 | 0.000149 | CXCL10, CCL5 |